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TH-588
CAS No. 1609960-31-7
TH-588( TH588 )
Catalog No. M12322 CAS No. 1609960-31-7
A potent and selective inhibitor of MTH1 protein with IC50 of 5 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 60 | In Stock |
|
| 2MG | 33 | In Stock |
|
| 5MG | 54 | In Stock |
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| 10MG | 79 | In Stock |
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| 25MG | 122 | In Stock |
|
| 50MG | 203 | In Stock |
|
| 100MG | 381 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTH-588
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective inhibitor of MTH1 protein with IC50 of 5 nM.
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DescriptionA potent and selective inhibitor of MTH1 protein with IC50 of 5 nM; shows no relevant inhibition for MTH2,NUDT5, NUDT12,NUDT14,NUDT16 and other proteinswith known nucleoside triphosphate pyrophosphatase activity; causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.
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In VitroCell Viability Assay Cell Line:U2OS, HeLa, MDA-MB-231, MCF-7, SW480, SW620, VH10, HDFn cells Concentration:2, 4, 6, 8, 10 μM Incubation Time:7-10 days Result:Selectively and effectively killed U2OS, HeLa, MDA-MB-231, MCF-7, SW480, and SW620 cells with IC50s of 1.38, 0.83, 1.03, 1.08, 1.72, 0.8 μM, but was less toxic to several primary or immortalized cells.
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In VivoAnimal Model:5-6 weeks female SCID mice (SW480 xenograft cancer model)Dosage:30 mg/kg Administration:Subcutaneous injection; once daily for 35 days Result:Reduced tumour growth in SW480 xenograft cancer model.
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SynonymsTH588
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorMTH1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1609960-31-7
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Formula Weight295.1672
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Molecular FormulaC13H12Cl2N4
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Purity>98% (HPLC)
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SolubilityDMSO: 16 mg/mL
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SMILESNC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC3CC3)=N1
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Chemical Name2,4-Pyrimidinediamine, N4-cyclopropyl-6-(2,3-dichlorophenyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gad H, et al. Nature. 2014 Apr 10;508(7495):215-21.
2. Wang M, et al. Sci Rep. 2017 Jan 11;7:40557.
3. Warpman Berglund U, et al. Ann Oncol. 2016 Dec;27(12):2275-2283.
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