Afobazole hydrochloride

Research use only, not for human use.

Fabomotizole HCl (CM346 HCl), an anxiolytic drug, produces anxiolytic and neuroprotective effects.

Fabomotizole HCl (CM346 HCl), an anxiolytic drug, produces anxiolytic and neuroprotective effects. The mechanism of Afobazole remains poorly defined, however, with GABAergic, NGF, and BDNF release promoting, MT1 receptor antagonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Afobazole inhibits MAO-A reversibly and there might be also some involvement with serotonin receptors.(In Vitro):Afobazole's mechanism of action remains poorly defined however, with GABAergic, NGF and BDNF release promoting, MT1 receptor antagonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Afobazole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Afobazole has found little clinical use outside of Russia and has not been evaluated by the FDA.

Afobazole's mechanism of action remains poorly defined however, with GABAergic, NGF and BDNF release promoting, MT1 receptor antagonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Afobazole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Afobazole has found little clinical use outside of Russia and has not been evaluated by the FDA.

——

CM346 hydrochloride

Cell Cycle/DNA Damage

DNA/RNA Synthesis

Others

Neurological Disease

——

173352-39-1

343.87

C15H22ClN3O2S

>98% (HPLC)

DMSO : ≥ 44 mg/mL 127.96 mM

CCOc1cc2c(cc1)nc([nH]2)SCCN1CCOCC1.Cl

——

(-20℃)

With Ice Pack

≥ 2 years