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RI-1
CAS No. 415713-60-9
RI-1( RI-1 | RI1 | RI 1 )
Catalog No. M14422 CAS No. 415713-60-9
RI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 63 | In Stock |
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| 2MG | 35 | In Stock |
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| 5MG | 56 | In Stock |
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| 10MG | 100 | In Stock |
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| 25MG | 154 | In Stock |
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| 50MG | 184 | In Stock |
|
| 100MG | 343 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRI-1
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NoteResearch use only, not for human use.
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Brief DescriptionRI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30μM.
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DescriptionRI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30μM.
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In VitroRI-1 (1-50 μM; 24 h) specifically inhibits homologous recombination (HR) in U2OS cells and stimulates single-strand annealing (SSA) in HEK293 cells.?RI-1 (5-20 μM; 30 min) inhibits HsRAD51 in a concentration-dependent manner.RI-1 (20 μM; 8 h) disrupts the formation of RAD51 foci after DNA damage in immortalized human fibroblasts.?RI-1 (15-25 μM; 24 h) sensitizes human cancer cells (HeLa, MCF-7 and U2OS) to cross-linking chemotherapy.
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In VivoRI-1 (50 mg/kg; i.p. every 3 d for 30 d) significantly reduces triple negative breast cancer (TNBC) tumor growth in mice. Animal Model:Female BALB/c nude mice (6 weeks) bearing TNBC tumorDosage:50 mg/kg Administration:I.p. every 3 days for 30 days Result:Resulted in significant inhibition of tumor growth.
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SynonymsRI-1 | RI1 | RI 1
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorRAD51
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number415713-60-9
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Formula Weight361.61
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Molecular FormulaC14H11Cl3N2O3
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Purity>98% (HPLC)
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SolubilityDMSO: 50 mg/mL (138.27 mM)
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SMILESClC1=C(N2CCOCC2)C(=O)N(C1=O)C1=CC(Cl)=C(Cl)C=C1
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Chemical Name3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Budke B, et al. Nucleic Acids Res. 2012 Aug;40(15):7347-57.
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