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AG-636
CAS No. 1623416-31-8
AG-636( —— )
Catalog No. M23718 CAS No. 1623416-31-8
AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 170 | In Stock |
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| 5MG | 155 | In Stock |
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| 10MG | 250 | In Stock |
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| 25MG | 503 | In Stock |
|
| 50MG | 709 | In Stock |
|
| 100MG | 918 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAG-636
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NoteResearch use only, not for human use.
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Brief DescriptionAG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.
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DescriptionAG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.
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In Vitro——
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In VivoAnimal Model:Transgenic female 6-8-week-old CB17/Icr-Prkdcscid/IcrIcoCrl (CB17 SCID) mice injected with OCILY19 cells Dosage:10 mg/kg, 30 mg/kg, or 100 mg/kg Administration:Oral gavage; twice daily; for 14 days Result:Resulted in robust tumor growth inhibition in xenograft lymphoma tumor models.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetDehydrogenase
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RecptorDHODH|DNA/RNA Synthesis
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Research Area——
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Indication——
Chemical Information
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CAS Number1623416-31-8
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Formula Weight343.38
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Molecular FormulaC21H17N3O2
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Purity>98% (HPLC)
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SolubilityDMSO:31.25 mg/mL (91.01 mM; Need ultrasonic)
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SMILESO=C(C1=C(N(C)N=N2)C2=CC(C3=CC=C(C4=CC=CC=C4C)C=C3)=C1)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Gabrielle McDonald, et al. Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase. Mol Cancer Ther. 2020 Dec;19(12):2502-2515.
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