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UCB-9260
CAS No. 1515888-53-5
UCB-9260( —— )
Catalog No. M23652 CAS No. 1515888-53-5
UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 258 | In Stock |
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| 2MG | 136 | In Stock |
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| 5MG | 231 | In Stock |
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| 10MG | 372 | In Stock |
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| 25MG | 635 | In Stock |
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| 50MG | 830 | In Stock |
|
| 100MG | 1144 | In Stock |
|
| 200MG | 1535 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameUCB-9260
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NoteResearch use only, not for human use.
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Brief DescriptionUCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.
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DescriptionUCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.(In Vitro):UCB-9260 (0-10 μM) inhibits NF-κB with a geometric mean IC50 of 202 nM after TNF (10 pM) stimulation in in Hek-293 cells.UCB-9260 inhibits TNF-dependent cytotoxicity with a geometric mean IC50 of 116 nM and a geometric mean IC50 of 120 nM, using human and mouse TNF, respectively.(In Vivo):UCB-9260 (0-10 μM) inhibits NF-κB with a geometric mean IC50 of 202 nM after TNF (10 pM) stimulation in in Hek-293 cells.UCB-9260 inhibits TNF-dependent cytotoxicity with a geometric mean IC50 of 116 nM and a geometric mean IC50 of 120 nM, using human and mouse TNF, respectively.
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In Vitro——
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In VivoAnimal Model:Aged 6-8 weeks adult male Balb/c mice?(?CAIA model) Dosage:150?mg/kg Administration:p.o.; twice daily for 7days?Result:Showed a significant reduction of the clinical score.
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Synonyms——
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PathwayApoptosis
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TargetTNF
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RecptorTNF
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Research Area——
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Indication——
Chemical Information
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CAS Number1515888-53-5
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Formula Weight423.51
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Molecular FormulaC26H25N5O
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Purity>98% (HPLC)
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SolubilityDMSO:10 mM
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SMILESOC(C1=CC=NC=C1)C2=NC3=CC=C(C4=CN(C)N=C4)C=C3N2CC5=CC(C)=CC=C5C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.O'Connell J, et al.Small?molecules?that?inhibit?TNF?signalling?by?stabilising?an?asymmetric?form?of the?trimer.Nat Commun.?2019 Dec 19;10(1):5795.
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