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BC-1258

CAS No. 1507370-40-2

BC-1258( —— )

Catalog No. M23649 CAS No. 1507370-40-2

BC-1258 is a unique small molecule F-box/LRR-repeat protein 2 (FBXL2) activator.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 35 In Stock
5MG 29 In Stock
10MG 44 In Stock
25MG 93 In Stock
100MG Get Quote In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    BC-1258
  • Note
    Research use only, not for human use.
  • Brief Description
    BC-1258 is a unique small molecule F-box/LRR-repeat protein 2 (FBXL2) activator.
  • Description
    BC-1258 is a unique small molecule F-box/LRR-repeat protein 2 (FBXL2) activator.
  • In Vitro
    Cell Cycle Analysis Cell Line:MLE cells Concentration:2, 10, 50 μg/mL Incubation Time:16 hours Result:Significantly increased the cell population within the G2/M phase.Reduced the diploid cell population and increase the numbers of polyploidal cells in a dose-dependent manner.Western Blot Analysis Cell Line:U937, K562 and THP1 cells Concentration:2, 10 μg/mL Incubation Time:16 hours Result:Increased FBXL2 protein levels.Decreased FBXL2 substrates, including Aurora B, cyclin D2 and cyclin D3 levels.
  • In Vivo
    BC-1258 (30 μg/mL in the drinking water) significantly reduces tumor size and weight in athymic nude mice.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    FBXL2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1507370-40-2
  • Formula Weight
    406.57
  • Molecular Formula
    C22H22N4S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    C1=CC(=CC=C1CNCCNCC2=CC=C(C=C2)C3=NC=CS3)C4=NC=CS4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Chen B B , Glasser J R , Coon T A , et al. Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis[J]. Cell Death & Disease, 2013, 4(8):e759.
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