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BC-1258
CAS No. 1507370-40-2
BC-1258( —— )
Catalog No. M23649 CAS No. 1507370-40-2
BC-1258 is a unique small molecule F-box/LRR-repeat protein 2 (FBXL2) activator.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 35 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 44 | In Stock |
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| 25MG | 93 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBC-1258
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NoteResearch use only, not for human use.
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Brief DescriptionBC-1258 is a unique small molecule F-box/LRR-repeat protein 2 (FBXL2) activator.
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DescriptionBC-1258 is a unique small molecule F-box/LRR-repeat protein 2 (FBXL2) activator.
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In VitroCell Cycle Analysis Cell Line:MLE cells Concentration:2, 10, 50 μg/mL Incubation Time:16 hours Result:Significantly increased the cell population within the G2/M phase.Reduced the diploid cell population and increase the numbers of polyploidal cells in a dose-dependent manner.Western Blot Analysis Cell Line:U937, K562 and THP1 cells Concentration:2, 10 μg/mL Incubation Time:16 hours Result:Increased FBXL2 protein levels.Decreased FBXL2 substrates, including Aurora B, cyclin D2 and cyclin D3 levels.
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In VivoBC-1258 (30 μg/mL in the drinking water) significantly reduces tumor size and weight in athymic nude mice.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorFBXL2
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Research Area——
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Indication——
Chemical Information
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CAS Number1507370-40-2
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Formula Weight406.57
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Molecular FormulaC22H22N4S2
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Purity>98% (HPLC)
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SolubilityDMSO:10 mM
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SMILESC1=CC(=CC=C1CNCCNCC2=CC=C(C=C2)C3=NC=CS3)C4=NC=CS4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Chen B B , Glasser J R , Coon T A , et al. Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis[J]. Cell Death & Disease, 2013, 4(8):e759.
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