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SIRT-IN-2
CAS No. 1431411-66-3
SIRT-IN-2( —— )
Catalog No. M23596 CAS No. 1431411-66-3
SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 250 | In Stock |
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| 5MG | 227 | In Stock |
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| 10MG | 364 | In Stock |
|
| 25MG | 620 | In Stock |
|
| 50MG | 830 | In Stock |
|
| 100MG | 1135 | In Stock |
|
| 200MG | 1516 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSIRT-IN-2
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NoteResearch use only, not for human use.
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Brief DescriptionSIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).
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DescriptionSIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).
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In VitroSIRT-IN-2 (compound 31) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 4, 4, 7 μM, respectively. SIRT-IN-2 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 ?), occupying the nicotinamide C-pocket and acetyl lysine substrate channel.
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetSirtuin
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RecptorSIRT1|SIRT2|SIRT3
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Research Area——
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Indication——
Chemical Information
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CAS Number1431411-66-3
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Formula Weight383.49
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Molecular FormulaC15H21N5O3S2
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Purity>98% (HPLC)
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SolubilityDMSO:62.5 mg/mL?(151.24 mM;?Need ultrasonic)
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SMILESCS(NCCC(CC1)CCN1c1ncnc2c1sc(C(N)=O)c2)(=O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56(9):3666-79.
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