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PH-002

CAS No. 1311174-68-1

PH-002( —— )

Catalog No. M23470 CAS No. 1311174-68-1

PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells. It also could rescue impairments of mitochondrial motility and neurite outgrowth.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 103 In Stock
5MG 92 In Stock
10MG 155 In Stock
25MG 345 In Stock
50MG 548 In Stock
100MG 784 In Stock
200MG 1079 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    PH-002
  • Note
    Research use only, not for human use.
  • Brief Description
    PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells. It also could rescue impairments of mitochondrial motility and neurite outgrowth.
  • Description
    PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells. It also could rescue impairments of mitochondrial motility and neurite outgrowth.
  • In Vitro
    PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells, with an IC50 of 116 nM in FRET.
  • In Vivo
    PH-002 is also shown to increase COX1 levels in primary neurons from NSE-apoE4 transgenic mouse cortex and hippocampus. After 4 days of treatment with PH-002 (200 nM), COX1 levels are increased by ~60%. PH-002 (100 nM) increases dendritic spine development in primary neurons from NSE-apoE4 transgenic mice to levels comparable with those in NSE-apoE3 primary neurons (apoE3-expressing primary neurons treated with PH-002 gave results identical to untreated primary neurons).
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Apo E4 in FRET
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1311174-68-1
  • Formula Weight
    491.58
  • Molecular Formula
    C27H33N5O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:75 mg/mL (152.57 mM)
  • SMILES
    CC(C)(C)OC(N1CCN(Cc(cc2)ccc2NC(CC(c2c3cccc2)=NN(C)C3=O)=O)CC1)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Brodbeck J, et al. Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors. J Biol Chem. 2011 May 13;286(19):17217-26.
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