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PH-002
CAS No. 1311174-68-1
PH-002( —— )
Catalog No. M23470 CAS No. 1311174-68-1
PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells. It also could rescue impairments of mitochondrial motility and neurite outgrowth.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 103 | In Stock |
|
| 5MG | 92 | In Stock |
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| 10MG | 155 | In Stock |
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| 25MG | 345 | In Stock |
|
| 50MG | 548 | In Stock |
|
| 100MG | 784 | In Stock |
|
| 200MG | 1079 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePH-002
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NoteResearch use only, not for human use.
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Brief DescriptionPH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells. It also could rescue impairments of mitochondrial motility and neurite outgrowth.
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DescriptionPH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells. It also could rescue impairments of mitochondrial motility and neurite outgrowth.
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In VitroPH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells, with an IC50 of 116 nM in FRET.
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In VivoPH-002 is also shown to increase COX1 levels in primary neurons from NSE-apoE4 transgenic mouse cortex and hippocampus. After 4 days of treatment with PH-002 (200 nM), COX1 levels are increased by ~60%. PH-002 (100 nM) increases dendritic spine development in primary neurons from NSE-apoE4 transgenic mice to levels comparable with those in NSE-apoE3 primary neurons (apoE3-expressing primary neurons treated with PH-002 gave results identical to untreated primary neurons).
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorApo E4 in FRET
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Research Area——
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Indication——
Chemical Information
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CAS Number1311174-68-1
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Formula Weight491.58
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Molecular FormulaC27H33N5O4
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Purity>98% (HPLC)
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SolubilityDMSO:75 mg/mL (152.57 mM)
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SMILESCC(C)(C)OC(N1CCN(Cc(cc2)ccc2NC(CC(c2c3cccc2)=NN(C)C3=O)=O)CC1)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Brodbeck J, et al. Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors. J Biol Chem. 2011 May 13;286(19):17217-26.
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