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653-47 hydrochloride
CAS No. 1224567-46-7
653-47 hydrochloride( —— )
Catalog No. M23394 CAS No. 1224567-46-7
653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 177 | In Stock |
|
| 10MG | 335 | In Stock |
|
| 25MG | 566 | In Stock |
|
| 50MG | 806 | In Stock |
|
| 100MG | 1098 | In Stock |
|
| 500MG | 2205 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Name653-47 hydrochloride
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NoteResearch use only, not for human use.
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Brief Description653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15.
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Description653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. It is also a very weak CREB inhibitor with IC50 of 26.3 μM.
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In Vitro653-47 (5-10 μM) synergistically inhibits CREB-mediated gene transcription with 666-15.
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetEpigenetic Reader Domain
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RecptorCREB
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Research Area——
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Indication——
Chemical Information
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CAS Number1224567-46-7
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Formula Weight407.29
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Molecular FormulaC20H20Cl2N2O3
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Purity>98% (HPLC)
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SolubilityDMSO:250 mg/mL?(613.81 mM;?Need ultrasonic)
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SMILESO=C(NC1=CC=C(C=C1O)Cl)C2=C(C=C3C=CC=CC3=C2)OCCCN.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Xie F, et al. Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666-15. J Med Chem. 2019;62(24):11423-11429.
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