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Home - Products - Chromatin/Epigenetic - Epigenetic Reader Domain - 653-47 hydrochloride

653-47 hydrochloride

CAS No. 1224567-46-7

653-47 hydrochloride( —— )

Catalog No. M23394 CAS No. 1224567-46-7

653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 215 In Stock
5MG 187 In Stock
10MG 353 In Stock
25MG 598 In Stock
50MG 833 In Stock
100MG 1135 In Stock
200MG Get Quote In Stock
500MG 2279 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    653-47 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15.
  • Description
    653-47 hydrochloride is a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. It is also a very weak CREB inhibitor with IC50 of 26.3 μM.
  • In Vitro
    653-47 (5-10 μM) synergistically inhibits CREB-mediated gene transcription with 666-15.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Epigenetic Reader Domain
  • Recptor
    CREB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1224567-46-7
  • Formula Weight
    407.29
  • Molecular Formula
    C20H20Cl2N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:250 mg/mL?(613.81 mM;?Need ultrasonic)
  • SMILES
    O=C(NC1=CC=C(C=C1O)Cl)C2=C(C=C3C=CC=CC3=C2)OCCCN.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Xie F, et al. Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666-15. J Med Chem. 2019;62(24):11423-11429.
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