SRX3177

CAS No. 2241237-51-2

SRX3177( —— )

Catalog No. M36306 CAS No. 2241237-51-2

SRX3177 is a novel and potent inhibitor of BRD4, PI3K and CDK.SRX3177 has potential anticancer activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 208 In Stock
5MG 160 In Stock
10MG 240 In Stock
25MG 408 In Stock
50MG 550 In Stock
100MG 784 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    SRX3177
  • Note
    Research use only, not for human use.
  • Brief Description
    SRX3177 is a novel and potent inhibitor of BRD4, PI3K and CDK.SRX3177 has potential anticancer activity.
  • Description
    SRX3177 is a triple inhibitor of CDK4/6, PI3K, and BRD4, with IC50s of 33 nM (BRD4 BD1), 89 nM (BRD4 BD2), 79 nM (PI3Kα), 83 nM (PI3Kδ), 3.18 μM (PI3Kγ), <2.5 nM (CDK4), 3.3 nM (CDK6), respectively. SRX3177 exerts broad cytotoxic activity against cancer cells, but acts friendly with normal epithelial cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Epigenetic Reader Domain
  • Recptor
    Epigenetic Reader Domain | PI3K | CDK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2241237-51-2
  • Formula Weight
    584.69
  • Molecular Formula
    C31H32N6O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (42.76 mM; Ultrasonic )
  • SMILES
    C(N(C)C)(=O)C=1N(C=2C(C1)=CN=C(NC3=CC=C(C=C3)C=4C5=C(SC4)C(=O)C=C(O5)N6CCOCC6)N2)C7CCCC7
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Burgoyne AM, et al. A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity. Cell Discov. 2020 Jul 28;6(1):49.?
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