SRX3177( —— )

Catalog No. M36306 CAS No. 2241237-51-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SRX3177
Note

Research use only, not for human use.
Brief Description

SRX3177 is a novel and potent inhibitor of BRD4, PI3K and CDK.SRX3177 has potential anticancer activity.
Description

SRX3177 is a triple inhibitor of CDK4/6, PI3K, and BRD4, with IC50s of 33 nM (BRD4 BD1), 89 nM (BRD4 BD2), 79 nM (PI3Kα), 83 nM (PI3Kδ), 3.18 μM (PI3Kγ), <2.5 nM (CDK4), 3.3 nM (CDK6), respectively. SRX3177 exerts broad cytotoxic activity against cancer cells, but acts friendly with normal epithelial cells.
In Vitro

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In Vivo

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Synonyms

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Pathway

Chromatin/Epigenetic
Target

Epigenetic Reader Domain
Recptor

Epigenetic Reader Domain | PI3K | CDK
Research Area

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Indication

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CAS Number

2241237-51-2
Formula Weight

584.69
Molecular Formula

C31H32N6O4S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 25 mg/mL (42.76 mM; Ultrasonic )
SMILES

C(N(C)C)(=O)C=1N(C=2C(C1)=CN=C(NC3=CC=C(C=C3)C=4C5=C(SC4)C(=O)C=C(O5)N6CCOCC6)N2)C7CCCC7
Chemical Name

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1. Burgoyne AM, et al. A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity. Cell Discov. 2020 Jul 28;6(1):49.?

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