SCH-37370( SCH 37370 | SCH37370 )

Catalog No. M23344 CAS No. 117796-52-8

SCH-37370 is an effective and orally active dual antagonist of platelet-activating factor and histamine.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

SCH-37370
Note

Research use only, not for human use.
Brief Description

SCH-37370 is an effective and orally active dual antagonist of platelet-activating factor and histamine.
Description

SCH-37370 is an effective and orally active dual antagonist of platelet-activating factor and histamine. Sch 37370 blocks the binding of [3H]pyrilamine to histamine-H1 receptors in rat brain membranes. Sch 37370 selectively inhibits PAF-induced aggregation of human platelets (IC50 : 0.6 mM) and also competes with PAF binding to specific sites in membrane preparations from human lungs (IC50 : 1.2 mM).
In Vitro

——
In Vivo

——
Synonyms

SCH 37370 | SCH37370
Pathway

Others
Target

Other Targets
Recptor

PAF
Research Area

——
Indication

——

Chemical Information

CAS Number

117796-52-8
Formula Weight

352.86
Molecular Formula

C21H21ClN2O
Purity

>98% (HPLC)
Solubility

DMSO:Soluble
SMILES

CC(N(CC1)CCC1=C(c(cc1)c(CC2)cc1Cl)c1c2cccn1)=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Kaminski JJ, Carruthers NI, Wong SC, Chan TM, Billah MM, Tozzi S, McPhail AT. Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine. Bioorg Med Chem. 1999 Jul;7(7):1413-23. PubMed PMID: 10465415.

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