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Talacotuzumab
CAS No. 1826831-79-1
Talacotuzumab( —— )
Catalog No. M36759 CAS No. 1826831-79-1
Talacotuzumab (JNJ 56022473) is an IgG1 fully humanized CD123 neutralizing monoclonal antibody containing a modified Fc structure.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 943 | In Stock |
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| 10MG | 1311 | In Stock |
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| 25MG | 1881 | In Stock |
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| 50MG | 2623 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTalacotuzumab
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NoteResearch use only, not for human use.
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Brief DescriptionTalacotuzumab (JNJ 56022473) is an IgG1 fully humanized CD123 neutralizing monoclonal antibody containing a modified Fc structure.
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DescriptionTalacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized, CD123-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has KDs of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models.
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In Vitro——
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In VivoAnimal Model:Nonobese diabetic/severe combined immunodeficiency mice injected intravenously AML xenograft cells (AML-5)Dosage:300 μg Administration:IP; thrice weekly for 5 weeks Result:Resulted in a significant delay in tumor growth compared with an isotype control.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorInterleukin | Immunology/Inflammation related
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Research Area——
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Indication——
Chemical Information
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CAS Number1826831-79-1
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Formula Weight
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Molecular Formula——
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. S J Busfield, et al. Targeting of acute myeloid leukemia in vitro and in vivo with an anti-CD123 mAb engineered for optimal ADCC. Leukemia. 2014 Nov;28(11):2213-21.?
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