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Isolongifolene

CAS No. 1135-66-6

Isolongifolene( (-)-Isolongifolene )

Catalog No. M23324 CAS No. 1135-66-6

Isolongifolene has antioxidant, anti-inflammatory, anticancer and neuroprotective properties.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 103 In Stock
2MG 56 In Stock
5MG 93 In Stock
10MG 148 In Stock
25MG 250 In Stock
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Biological Information

  • Product Name
    Isolongifolene
  • Note
    Research use only, not for human use.
  • Brief Description
    Isolongifolene has antioxidant, anti-inflammatory, anticancer and neuroprotective properties.
  • Description
    Isolongifolene has antioxidant, anti-inflammatory, anticancer and neuroprotective properties. Isolongifolene is a tricyclic sesquiterpene isolated from Murraya koenigii. Isolongifolene attenuates Rotenone-induced oxidative stress, mitochondrial dysfunction and apoptosis through the regulation of P13K/AKT/GSK-3β signaling pathways.
  • In Vitro
    Isolongifolene (0-50 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment significantly alleviates Rotenone-induced cytotoxicity in SH-SY5Y cells in a dose-dependent manner.Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone-induced apoptosis in SH-SY5Y cells.Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Furthermore regulation of p-P13K, p-AKT and p-GSK-3β expression by Isolongifolene. Cell Viability Assay Cell Line:SH-SY5Y neuroblastoma cells Concentration:0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM and 50 μM Incubation Time:26 hours Result:Significantly alleviated Rotenone-induced cytotoxicity in SH-SY5Y cells.Apoptosis Analysis Cell Line:SH-SY5Y neuroblastoma cells Concentration:10 μMIncubation Time:26 hours Result:Attenuated Rotenone-induced apoptosis in SH-SY5Y cells.Western Blot AnalysisCell Line:SH-SY5Y neuroblastoma cells Concentration:10 μM Incubation Time:26 hours Result:Attenuated rotenone induced toxicity by down-regulatingBax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Prevented the rotenone-induced decreased phosphorylation of GSK-3β.
  • In Vivo
    ——
  • Synonyms
    (-)-Isolongifolene
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1135-66-6
  • Formula Weight
    204.35
  • Molecular Formula
    C15H24
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    CC1(C)[C@]23CC[C@](C3)([H])C(C)(C)C2=CCC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Balakrishnan R, et al. Isolongifolene attenuates rotenone-induced mitochondrial dysfunction, oxidative stress and apoptosis. Front Biosci (Schol Ed). 2018 Jan 1;10:248-261.
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