Deoxycorticosterone acetate( Deoxycorticosterone Acetate | DOCA | Percotol | Cortexone acetate | )

Catalog No. M15055 CAS No. 56-47-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Deoxycorticosterone acetate
Note

Research use only, not for human use.
Brief Description

Deoxycorticosterone acetate is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid.
Description

Deoxycorticosterone acetate is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid.
In Vitro

——
In Vivo

Animal Model:MR (mineralocorticoid receptor) mutant mice (MRCdh5Cre)?and MR wild-type mice (MRwild-type) treated with unilateral nephrectomy (12-week-old) Dosage:2.5 mg/d Administration:Subcutaneous implantation; 42 days; treated with 2 mg Tamoxifen (HY-13757A) (20?mg/mL in sunflower oil and 10% ethanol; i.p.; once daily on?5 consecutive days) at least 4 weeks before nephrectomy Result:Increased the blood pressure without differences between both genotypes (MRCdh5Cre and MRwild-type).Resulted glomerular injury and proteinuria, renal inflammation and fibrosis.
Synonyms

Deoxycorticosterone Acetate | DOCA | Percotol | Cortexone acetate |
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Endocrinology
Indication

——

CAS Number

56-47-3
Formula Weight

372.5
Molecular Formula

C23H32O4
Purity

>98% (HPLC)
Solubility

Ethanol: 6 mg/mL (16.1 mM); DMSO: 11 mg/mL (29.53 mM)
SMILES

CC(OCC([C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O)=O)=O
Chemical Name

[2-[(8S,9S,10R,13S,14S,17S)-10,13-Dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate

1.Schenk J, et al. J Pharmacol Toxicol Methods, 1992, 27(3), 161-70.

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