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IAXO-102
CAS No. 1115270-63-7
IAXO-102( —— )
Catalog No. M23313 CAS No. 1115270-63-7
IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 129 | In Stock |
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| 5MG | 250 | In Stock |
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| 10MG | 401 | In Stock |
|
| 25MG | 655 | In Stock |
|
| 50MG | 912 | In Stock |
|
| 100MG | 1256 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameIAXO-102
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NoteResearch use only, not for human use.
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Brief DescriptionIAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling.
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DescriptionIAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development.
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In VitroWestern Blot Analysis Cell Line:Human umbilical vein endothelial (HUVEC) cells Concentration:1-10 μM Incubation Time:Pretreatment for 1 hour and then exposed to LPS (100 ng/mL) for additional 1 hour Result:Significantly inhibited LPS-stimulated MAPK/p65nF-ΚB phosphorylation.
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In VivoAnimal Model:Six-monthold ApoE?/?/C57Bl6 Dosage:3 mg/kg/day Administration:S.C. for 28 days Result:Significantly retarded Angiotensin II-induced increase in aortic diameter.
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Synonyms——
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PathwayImmunology/Inflammation
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TargetTLR
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RecptorTLR4
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Research Area——
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Indication——
Chemical Information
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CAS Number1115270-63-7
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Formula Weight585.94
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Molecular FormulaC35H71NO5
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Purity>98% (HPLC)
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SolubilityEthanol:45 mg/mL (76.8 mM; Need ultrasonic);DMSO:< 1 mg/mL (insoluble or slightly soluble)
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SMILESCCCCCCCCCCCCCCO[C@@H]([C@@H]([C@@H](CN)O[C@@H]1OC)O)[C@H]1OCCCCCCCCCCCCCC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Huggins C, et al. A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development. Atherosclerosis. 2015 Oct;242(2):563-70.
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