Afoxolaner
CAS No. 1093861-60-9
Afoxolaner( —— )
Catalog No. M23298 CAS No. 1093861-60-9
Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 48 | In Stock |
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| 5MG | 34 | In Stock |
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| 10MG | 58 | In Stock |
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| 25MG | 111 | In Stock |
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| 50MG | 178 | In Stock |
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| 100MG | 277 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAfoxolaner
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NoteResearch use only, not for human use.
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Brief DescriptionAfoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs.
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DescriptionAfoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod.
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In Vitro——
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In VivoA single oral treatment with a dose approaching the minimum effective dose of Afoxolaner (2.5mg/kg) eliminated the pre-existing infestations of I. scapularis ticks and controlled weekly re-infestations, with efficacy between 98% and 100% recorded until Day 23 and 94% at Day 30.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetChloride Channel
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RecptorChloride Channel|GABA|Parasite
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Research Area——
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Indication——
Chemical Information
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CAS Number1093861-60-9
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Formula Weight625.87
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Molecular FormulaC26H17ClF9N3O3
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Purity>98% (HPLC)
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SolubilityDMSO: 250 mg/mL (399.44 mM)
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SMILESO=C(CNC(c1ccc(C(C2)=NOC2(C(F)(F)F)c2cc(C(F)(F)F)cc(Cl)c2)c2ccccc12)=O)NCC(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Mitchell EB, et al. Efficacy of afoxolaner against Ixodes scapularis ticks in dogs.Vet Parasitol.?2014 Apr 2;201(3-4):223-5.
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