Afoxolaner( —— )

Catalog No. M23298 CAS No. 1093861-60-9

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Product Name

Afoxolaner
Note

Research use only, not for human use.
Brief Description

Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs.
Description

Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod.
In Vitro

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In Vivo

A single oral treatment with a dose approaching the minimum effective dose of Afoxolaner (2.5mg/kg) eliminated the pre-existing infestations of I. scapularis ticks and controlled weekly re-infestations, with efficacy between 98% and 100% recorded until Day 23 and 94% at Day 30.
Synonyms

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Pathway

Membrane Transporter/Ion Channel
Target

Chloride Channel
Recptor

Chloride Channel|GABA|Parasite
Research Area

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Indication

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CAS Number

1093861-60-9
Formula Weight

625.87
Molecular Formula

C26H17ClF9N3O3
Purity

>98% (HPLC)
Solubility

DMSO: 250 mg/mL (399.44 mM)
SMILES

O=C(CNC(c1ccc(C(C2)=NOC2(C(F)(F)F)c2cc(C(F)(F)F)cc(Cl)c2)c2ccccc12)=O)NCC(F)(F)F
Chemical Name

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1.Mitchell EB, et al. Efficacy of afoxolaner against Ixodes scapularis ticks in dogs.Vet Parasitol.?2014 Apr 2;201(3-4):223-5.

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