1-(2-Amino-5-hydroxyphenyl)propan-1-one( —— )

Catalog No. M23109 CAS No. 35364-15-9

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Datasheet

HNMR

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Product Name

1-(2-Amino-5-hydroxyphenyl)propan-1-one
Note

Research use only, not for human use.
Brief Description

1-(2-Amino-5-hydroxyphenyl)propan-1-one is a useful synthetic intermediate.
Description

1-(2-Amino-5-hydroxyphenyl)propan-1-one is a useful synthetic intermediate. It is used in the asymmetrical synthesis of (S)-4-ethyl-6,7,8,10- tetrahydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione, a key intermediate for synthesis of irinotecan and other camptothecin analogs. It is also used in the synthesis of E- ring- modified (RS) - camptothecin analogs as antitumor agents.
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Indication

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1.Henegar, K., et al.: J. Org. Chem., 62, 6588 (1997); Ejima, A., et al.: Chem. Pharma. Bull., 40, 683 (1992)

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