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RS09 2TFA 1449566-36-2(free base)
CAS No. ——
RS09 2TFA 1449566-36-2(free base)( —— )
Catalog No. M23000 CAS No. ——
RS09 2TFA is a TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. It acts as an adjuvant in vivo and enhances X-15 specific antibody serum concentrations.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
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| 10MG | 607 | In Stock |
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| 25MG | 892 | In Stock |
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| 50MG | 1366 | In Stock |
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| 100MG | Get Quote | In Stock |
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Biological Information
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Product NameRS09 2TFA 1449566-36-2(free base)
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NoteResearch use only, not for human use.
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Brief DescriptionRS09 2TFA is a TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. It acts as an adjuvant in vivo and enhances X-15 specific antibody serum concentrations.
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DescriptionRS09 2TFA is a TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. It acts as an adjuvant in vivo and enhances X-15 specific antibody serum concentrations.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayImmunology/Inflammation
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TargetTLR
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RecptorTLR4
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight919.82
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Molecular FormulaC35H51F6N9O13
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(O)C(F)(F)F.O=C(O)C(F)(F)F.OC[C@@H](C(O)=O)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CC1=CNC=N1)NC([C@H]2N(C([C@H]3N(C([C@H](C)N)=O)CCC3)=O)CCC2)=O)=O)=O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Poly(I:C)
Poly (I:C) is a synthetic double-stranded RNA (dsRNA) analog and is an immunostimulant that acts as the most potent interferon (IFN) inducer. It also is a Toll-like receptor- 3 (TLR3) agonist.Mixtures that included the TLR7/8 agonists R848 or CL075, combined with the poly (I:C) can produce 3-d mature dendritic cells.
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CU-CPT9b
CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8;?Kd = 21 nM).?It inhibits activation of NF-?B induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells with an IC50 value of 0.7 nM.
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CU-CPT22
CU-CPT22 is the first probe for the complex between toll-like receptors TLR1 and TLR2.?CU-CPT22 binds at the interface of TLR1 and TLR2 (IC50 = 0.58 μM).?It competes with the synthetic triacylated lipoprotein (Pam3CSK4) binding to TLR1/2 (Ki: 0.41 μM).?
