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β-Elemene
CAS No. 515-13-9
β-Elemene( (-)-β-Elemene,Levo-β-elemene )
Catalog No. M22851 CAS No. 515-13-9
β-Elemene is a natural product isolated from Curcuma wenyujin, with an antitumor activity and induce cell apoptosis.β-Elemene significantly inhibited the metastatic capacity of MDR gastric cells in vivo and in vitro. Mechanistically, β-Elemene regulated MMP-2/9 expression and reversed epithelial-mesenchymal transition.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
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| 10MG | 38 | In Stock |
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| 25MG | 67 | In Stock |
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| 50MG | 104 | In Stock |
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| 100MG | 120 | In Stock |
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| 200MG | 179 | In Stock |
|
| 500MG | 303 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Nameβ-Elemene
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NoteResearch use only, not for human use.
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Brief Descriptionβ-Elemene is a natural product isolated from Curcuma wenyujin, with an antitumor activity and induce cell apoptosis.β-Elemene significantly inhibited the metastatic capacity of MDR gastric cells in vivo and in vitro. Mechanistically, β-Elemene regulated MMP-2/9 expression and reversed epithelial-mesenchymal transition.
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Descriptionβ-Elemene is a natural product isolated from Curcuma wenyujin, with an antitumor activity and induce cell apoptosis.β-Elemene significantly inhibited the metastatic capacity of MDR gastric cells in vivo and in vitro. Mechanistically, β-Elemene regulated MMP-2/9 expression and reversed epithelial-mesenchymal transition. β-Elemene upregulated Cbl-b expression, resulting in inhibition of the EGFR-ERK/AKT pathways, which regulate MMP-2/9. β-Elemene upregulated Cbl-b by inhibiting miR-1323 expression. Numbers of metastatic tumor nodules were significantly decreased in the lungs of nude mice after β-Elemene treatment. β-Elemene inhibits the metastasis of MDR gastric cancer cells by modulating the miR-1323/Cbl-b/EGFR signaling axis.
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In VitroCell Viability Assay Cell Line:T24, 5637, TCCSUP, J82, UM-UC-3, RT4 and SW780 cells Concentration:0, 6.25, 12.5, 25, 50, 100, 150 and 200 μg/ml Incubation Time:24 hours Result:Inhibited the proliferation of RT4, SW780, J82, UMUC-3, TCCSUP, 5637 and T24 human bladder cancer cells and SV-HUC-1 human urothelial cells.?Cell Cycle AnalysisCell Line:T24 and 5637 cells Concentration:0, 25, 50 and 75 μg/ml Incubation Time:24 hours Result:Induced the percentage of cells in the S-phase?as a dose-dependent manner.Western Blot AnalysisCell Line:T24 cells Concentration:50 μg/ml Incubation Time:24 hours Result:Downregulated p-STAT3 and cell cycle-related proteins.
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In Vivo——
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Synonyms(-)-β-Elemene,Levo-β-elemene
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PathwayApoptosis
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TargetApoptosis
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RecptorApoptosis
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Research Areacancer
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IndicationAnaplastic Oligoastrocytoma|Anaplastic Astrocytoma|Glioblastoma
Chemical Information
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CAS Number515-13-9
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Formula Weight204.35
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Molecular FormulaC15H24
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Purity>98% (HPLC)
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SolubilityDMSO:50 mg/mL (244.68 mM; Need ultrasonic)
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SMILESCC([C@H]1[C@@](C)(CC[C@@H](C(C)=C)C1)C=C)=C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ross, S.A., and ElSohly, M.A. The volatile oil composition of fresh and air-dried buds of Cannabis sativa. J. Nat. Prod. 59(1), 49-51 (1996).
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