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BAMB-4
CAS No. 891025-25-5
BAMB-4( ITPKA-IN-C14 )
Catalog No. M22707 CAS No. 891025-25-5
Bamb-4 is a highly membrane-permeable inhibitor of inositol-1,4,5-trisphosphate-3-kinase A (ITPKA). It acts by suppressing the metastasis-promoting effect of ITPKA in lung tumor cells(with IC50 of 37 μM in ADP-Glo Assay).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 119 | In Stock |
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| 2MG | 71 | In Stock |
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| 5MG | 113 | In Stock |
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| 10MG | 169 | In Stock |
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| 25MG | 318 | In Stock |
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| 50MG | 436 | In Stock |
|
| 100MG | 607 | In Stock |
|
| 200MG | 817 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBAMB-4
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NoteResearch use only, not for human use.
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Brief DescriptionBamb-4 is a highly membrane-permeable inhibitor of inositol-1,4,5-trisphosphate-3-kinase A (ITPKA). It acts by suppressing the metastasis-promoting effect of ITPKA in lung tumor cells(with IC50 of 37 μM in ADP-Glo Assay).
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DescriptionBamb-4 is a highly membrane-permeable inhibitor of inositol-1,4,5-trisphosphate-3-kinase A (ITPKA). It acts by suppressing the metastasis-promoting effect of ITPKA in lung tumor cells(with IC50 of 37 μM in ADP-Glo Assay).
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In VitroBAMB-4 (0.3-40 μM) has ITPKA inhibiton effect with an IC50 value of 37 μM.BAMB-4 (40 μM) inhibits InsP3 kinase activity with an IC50 value of 20 μM.BAMB-4 (100 μM, overnight) has high specificity and the high cellular uptake.BAMP-4 (0, 10, 20 and 40 μM) shows increased Km and decreased V max .BAMP-4 (0-30 μM) is a mixed type inhibitor with respect to ATP and InsP3 and does notonly affect binding of ATP but also binding of InsP3，which affects turnover of two substrate exhibit a higher inhibition specifcity.
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In Vivo——
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SynonymsITPKA-IN-C14
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PathwayOthers
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TargetOther Targets
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RecptorITPKA
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Research Area——
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Indication——
Chemical Information
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CAS Number891025-25-5
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Formula Weight252.27
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Molecular FormulaC15H12N2O2
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Purity>98% (HPLC)
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SolubilityDMSO:39 mg/mL(154.6 mM)
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SMILESCc1ccc(cc1)C(=O)Nc1noc2ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Schroder D, et al. Identification of a new membrane-permeable inhibitor against inositol-1,4,5-trisphosphate-3-kinase A. Biochem Biophys Res Commun. 2013 Sep 20;439(2):228-34.
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