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DS16570511

CAS No. ——

DS16570511( —— )

Catalog No. M22676 CAS No. ——

DS16570511 is a cellular osmotic inhibitor of mitochondrial calcium monoab, which blocks MCU or MICU1-dependent Ca2+ influx.DS16570511 dose - dependent inhibition of serum-induced mitochondrial Ca2+ influx in HEK293A cells with IC50 of 7 M.DS16570511 inhibits the uptake of isolated Ca2+. mitochondria from human cells, rat heart and pig heart.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    DS16570511
  • Note
    Research use only, not for human use.
  • Brief Description
    DS16570511 is a cellular osmotic inhibitor of mitochondrial calcium monoab, which blocks MCU or MICU1-dependent Ca2+ influx.DS16570511 dose - dependent inhibition of serum-induced mitochondrial Ca2+ influx in HEK293A cells with IC50 of 7 M.DS16570511 inhibits the uptake of isolated Ca2+. mitochondria from human cells, rat heart and pig heart.
  • Description
    DS16570511 is a cellular osmotic inhibitor of mitochondrial calcium monoab, which blocks MCU or MICU1-dependent Ca2+ influx.DS16570511 dose - dependent inhibition of serum-induced mitochondrial Ca2+ influx in HEK293A cells with IC50 of 7 M.DS16570511 inhibits the uptake of isolated Ca2+. mitochondria from human cells, rat heart and pig heart.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    mitochondrial calcium uniporter
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    562.44
  • Molecular Formula
    C30H25Cl2N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:124 mg/mL(220.47 mM)
  • SMILES
    Cc1onc(c1CNc1cccc(c1)C(=O)c1cn(CCCC(O)=O)c2ccccc12)-c1c(Cl)cccc1Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kon N, et al. DS16570511 is a small-molecule inhibitor of the mitochondrial calcium uniporter. Cell Death Discov. 2017 Jul 17;3:17045.
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