yGsy2p-IN-1( —— )

Catalog No. M22548 CAS No. 2415003-97-1

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Datasheet

HNMR

HPLC

MSDS

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Product Name

yGsy2p-IN-1
Note

Research use only, not for human use.
Brief Description

yGsy2p-IN-1 is a potent yeast glycogen synthase 2 (yGsy2p) and human glycogen synthase 1 (hGYS1) inhibitor. yGsy2p-IN-H23 a pyrazole inhibitor,and is used for glycogen storage diseases (GSDs)
Description

yGsy2p-IN-1 is a potent yeast glycogen synthase 2 (yGsy2p) and human glycogen synthase 1 (hGYS1) inhibitor. yGsy2p-IN-H23 a pyrazole inhibitor,and is used for glycogen storage diseases (GSDs).
In Vitro

yGsy2p-IN-1 (compound 23; 0.1, 1, 10, 100, 1000 μM) has IC50s of 7.89 μM and 33.6 μM for yGsy2p-WT and yGsy2p-Y513L. yGsy2p-IN-1 (100 μM) exhibits almost complete inhibition of synthase activity in both HEK293-PTG and Rat-1 cell lysates.
In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

yGsy2p|Hgys1
Research Area

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Indication

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1.Buyun Tang, et al. Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase. J Med Chem. 2020 Apr 9;63(7):3538-3551.

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