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Idelalisib (b)
CAS No. 1146702-54-6
Idelalisib (b)( CAL-101,GS-1101 )
Catalog No. M22532 CAS No. 1146702-54-6
Idelalisib is a selective inhibitor of p110δ(IC50 : 2.5 nM; in cell-free assays); shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 27 | In Stock |
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| 10MG | 39 | In Stock |
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| 25MG | 63 | In Stock |
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| 50MG | 80 | In Stock |
|
| 100MG | 115 | In Stock |
|
| 200MG | 174 | In Stock |
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| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameIdelalisib (b)
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NoteResearch use only, not for human use.
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Brief DescriptionIdelalisib is a selective inhibitor of p110δ(IC50 : 2.5 nM; in cell-free assays); shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.
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DescriptionIdelalisib is a selective inhibitor of p110δ(IC50 : 2.5 nM; in cell-free assays); shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.CAL-101 blocked constitutive phosphatidylinositol-3-kinase signaling, resulting in decreased phosphorylation of Akt and other downstream effectors, an increase in poly(ADP-ribose) polymerase and caspase cleavage and an induction of apoptosis.
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In Vitro——
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In Vivo——
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SynonymsCAL-101,GS-1101
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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Recptorp110δ
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Research Area——
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Indication——
Chemical Information
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CAS Number1146702-54-6
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Formula Weight415.42
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Molecular FormulaC22H18FN7O
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Purity>98% (HPLC)
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Solubility——
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SMILESCC[C@H](Nc1ncnc2nc[nH]c12)c1nc2cccc(F)c2c(=O)n1-c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Brian J Lannutti, Sarah A Meadows, Sarah E M Herman,et al.CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability.Blood. 2011 Jan 13;117(2):591-4.
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