Nicotinamide riboside

Research use only, not for human use.

Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities.

Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities.Nicotinamide riboside (NR) supplementation in mammalian cells and mouse tissues increases NAD(+) levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high-fat diet-induced metabolic abnormalities.The natural vitamin Nicotinamide riboside (NR) could be used as a nutritional supplement to ameliorate metabolic and age-related disorders characterized by defective mitochondrial function.

Nicotinamide riboside (0.5 nM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2.Nicotinamide riboside increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1000 μM.Nicotinamide riboside boosts NAD to restore antiviral poly(ADP-ribose) polymerase (PARP) functions to support innate immunity for coronavirus (CoVs), a cause of COVID-19.Western Blot Analysis Cell Line:HEK293T cells Concentration:0.5 nM Incubation Time:24 hours Result:Reduced the acetylation status of Ndufa9 and SOD2.

Chronic Nicotinamide riboside (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD+ content in a tissue-specific manner. Animal Model:10-week-old C57Bl/6J mice Dosage:400 mg/kg Administration:p.o.; daily; for 16 weeks Result:Increased plasma and intracellular NAD+ content in a tissue-specific manner.

——

Chromatin/Epigenetic

Sirtuin

SIRT1|SIRT3

——

——

1341-23-7

255.25

C11H15N2O5

>98% (HPLC)

——

NC(=O)c1ccc[n+](c1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

——

(-20℃)

With Ice Pack

≥ 2 years