CC-92480( —— )

Catalog No. M22448 CAS No. 2259648-80-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

CC-92480
Note

Research use only, not for human use.
Brief Description

CC-92480 is a cereblon E3 ubiquitin ligase modulating drug (CELMoD) with potent antimyeloma activity.CC-92480-induced loss of Aiolos and Ikaros in cultures of PBMCs resulted in the activation of T cells and increased production of IL-2 and IFN-γ. It exerts single-agent induction of apoptosis and exhibits remarkable synergy with NSC 34521. CC-92480 is effective in CC-4047, CC-5013, and CC-220-resistant cell lines.
Description

CC-92480 is a cereblon E3 ubiquitin ligase modulating drug (CELMoD) with potent antimyeloma activity.CC-92480-induced loss of Aiolos and Ikaros in cultures of PBMCs resulted in the activation of T cells and increased production of IL-2 and IFN-γ. It exerts single-agent induction of apoptosis and exhibits remarkable synergy with NSC 34521. CC-92480 is effective in CC-4047, CC-5013, and CC-220-resistant cell lines.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Proteasome/Ubiquitin
Target

E1
Recptor

E1/E2/E3 Enzyme
Research Area

Cancer
Indication

Multiple Myeloma

CAS Number

2259648-80-9
Formula Weight

567.61
Molecular Formula

C32H30FN5O4
Purity

>98% (HPLC)
Solubility

DMSO:5 mg/mL (8.81 mM; ultrasonic and warming and heat to 60°C)
SMILES

Fc1cc(ccc1N1CCN(Cc2ccc(COc3cccc4C(=O)N(Cc34)[C@H]3CCC(=O)NC3=O)cc2)CC1)C#N
Chemical Name

——