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NEO2734
CAS No. 2081072-29-7
NEO2734( EP31670 )
Catalog No. M22391 CAS No. 2081072-29-7
NEO2734 is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 302 | In Stock |
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| 5MG | 275 | In Stock |
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| 10MG | 454 | In Stock |
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| 25MG | 750 | In Stock |
|
| 50MG | 1004 | In Stock |
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| 100MG | 1376 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2762 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNEO2734
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NoteResearch use only, not for human use.
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Brief DescriptionNEO2734 is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).
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DescriptionNEO2734 is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).NEO2734, a novel dual inhibitor of BET and CBP/p300, is active in both hotspot mutant (F133V) and non-hotspot mutant (Q165P) PCa cells in vitro and in vivo.
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In VitroWestern Blot Analysis Cell Line:NUT carcinoma patient cell lines (TC-797 and PER-403).Concentration:1 μM.Incubation Time:6 h.Result:Results in greater loss of MYC protein.
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In VivoAnimal Model:Mice (PER-403 and 14169 models).Dosage:5, 8, 10 mg/kg Administration:Orally, once daily for 28 days.Result:Two of the three mice treated with NEO2734 were alive by day 100.Provided markedly improved survival compared with EP, i-BET-762, and even iBET-762+EP by day 100 following initiation of treatment.
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SynonymsEP31670
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PathwayChromatin/Epigenetic
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TargetEpigenetic Reader Domain
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Recptorp300/CBP|BET bromodomain
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Research Area——
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Indication——
Chemical Information
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CAS Number2081072-29-7
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Formula Weight435.44
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Molecular FormulaC22H24F3N3O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (229.65 mM)
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SMILESCc1cc(cn(C)c1=O)-c1ccc2nc(C3CCOCC3)n(CCOC(F)(F)F)c2c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer.
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