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TMBIM6 antagonist-1

CAS No. 123134-61-2

TMBIM6 antagonist-1( BIA )

Catalog No. M22371 CAS No. 123134-61-2

TMBIM6 antagonist-1 is an antagonist of TMBIM6.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 201 In Stock
2MG 117 In Stock
5MG 187 In Stock
10MG 315 In Stock
25MG 567 In Stock
50MG 792 In Stock
100MG 1088 In Stock
200MG Get Quote In Stock
500MG 2186 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    TMBIM6 antagonist-1
  • Note
    Research use only, not for human use.
  • Brief Description
    TMBIM6 antagonist-1 is an antagonist of TMBIM6.
  • Description
    TMBIM6 antagonist-1 is an antagonist of TMBIM6.
  • In Vitro
    Cell Viability Assay Cell Line:HT1080, MCF7, MDA-MB-2341 and SKBR3 cells.Concentration:0.5-10 μM.Incubation Time:3 days.Result:Inhibited cell viability.Western Blot Analysis Cell Line:WT and TMBIM6 KO HT1080 cells.Concentration:0, 2, 5 μM.Incubation Time:Result:Downregulated the protein levels of AKT-pS473.
  • In Vivo
    Animal Model:Six- to eight-week BklNbt:BALB/c/nu/nu old mice (HT1080 and MDA-MB-231 cells).Dosage:1?mg/kg.Administration:IP 5 days per week during 25 days.Result:Impaired cell-driven tumor growth.
  • Synonyms
    BIA
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    mTOR
  • Recptor
    TMBIM6
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    123134-61-2
  • Formula Weight
    268.27
  • Molecular Formula
    C15H12N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (186.38 mM)
  • SMILES
    Nc1ccccc1C(=O)\C=C\c1cccc(c1)[N+]([O-])=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kim H K , Bhattarai K R , Junjappa R P , et al. TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation[J]. Nature Communications, 2020, 11(1).
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