HS 024( —— )

Catalog No. M22357 CAS No. 212370-59-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

HS 024
Note

Research use only, not for human use.
Brief Description

Highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks α-MSH- and MTII-induced hypotension and bradycardia in rats, following central administration in vivo.
Description

Highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks α-MSH- and MTII-induced hypotension and bradycardia in rats, following central administration in vivo.
In Vitro

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In Vivo

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Synonyms

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Pathway

GPCR/G Protein
Target

Melanocortin Receptor
Recptor

melanocortin-4 receptor (MC4R)
Research Area

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Indication

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CAS Number

212370-59-7
Formula Weight

1266.5
Molecular Formula

C58H79N19O10S2
Purity

>98% (HPLC)
Solubility

water:0.50 mg/mL
SMILES

CCCC[C@@H]1NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O)NC(C)=O
Chemical Name

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1. Jonsson et al (2001) Melanocortin receptor agonist transiently increases oxygen consumption in rats. Neuroreport 12 3703 PMID:

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