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PF-00446687
CAS No. 862281-92-3
PF-00446687( PF-446687 | PF00446687 )
Catalog No. M16240 CAS No. 862281-92-3
PF-00446687 (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 267 | In Stock |
|
| 50MG | 1224 | In Stock |
|
| 100MG | 1674 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePF-00446687
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NoteResearch use only, not for human use.
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Brief DescriptionPF-00446687 (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM.
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DescriptionPF-00446687 (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM; displays >100-fold selectivity over MC1R/1 uM); is find to be active in preliminary human trials, with the 200mg dose being of similar effectiveness to 100mg sildenafil, though lower doses were ineffective.Sexual Dysfunction Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsPF-446687 | PF00446687
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PathwayGPCR/G Protein
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TargetMelanocortin Receptor
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RecptorMelanocortin Receptor
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Research AreaEndocrinology
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IndicationSexual Dysfunction
Chemical Information
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CAS Number862281-92-3
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Formula Weight470.593
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Molecular FormulaC28H36F2N2O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (132.81 mM)
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SMILESCC1CN(CC(C1(C2=CC=CC=C2)O)C)C(=O)C3CN(CC3C4=C(C=C(C=C4)F)F)C(C)(C)C
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Chemical Name[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[(3S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl]methanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lansdell MI, et al. J Med Chem. 2010 Apr 22;53(8):3183-97.
2. Modi ME, et al. Neuropsychopharmacology. 2015 Jul;40(8):1856-65.
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