Cyclic somatostatin( SRIF-14,Somatostatin-14 )

Catalog No. M22284 CAS No. 38916-34-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Cyclic somatostatin
Note

Research use only, not for human use.
Brief Description

Cyclic somatostatin is a cyclic tetradecapeptide regulating many endocrine and nervous system functions.
Description

Cyclic somatostatin is a cyclic tetradecapeptide regulating many endocrine and nervous system functions.
In Vitro

Cyclic somatostatin (0-10 μM; 15 min) dose-dependently inhibits the contractile response to isoprenaline in rat ventricular cardiomyocytes with an IC50 value of 13 nM.
In Vivo

Cyclic somatostatin (5 μg/kg; i.v. per hour once for 18-22 hours) affects visceral metabolism in ruminants. Animal Model:Polypay sheeps Dosage:5 μg/kg Administration:Intravenous injection; 5 μg/kg per hour once; for 18-22 hours Result:Decreased net portal-drained viscera release of glucose, a-amino N, ammonia N, b-hydrox ybutyrate, oxygen consumption, liver oxygen consumption, and total splanchnic a-amino N release and oxygen consumption. Increased lactate release and net hepatic glucose output.
Synonyms

SRIF-14,Somatostatin-14
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

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Indication

——

CAS Number

38916-34-6
Formula Weight

1637.88
Molecular Formula

C76H104N18O19S2
Purity

>98% (HPLC)
Solubility

DMF:100 mg/mL (61.05 mM; Need ultrasonic);H2O:71.3 mg/mL (43.53 mM; Need ultrasonic and warming)
SMILES

C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(O)=O)NC(=O)CNC(=O)[C@H](C)N)[C@@H](C)O
Chemical Name

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