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Home - Products - Metabolic Enzyme/Protease - PPAR - GW 6471

GW 6471

CAS No. 880635-03-0

GW 6471( —— )

Catalog No. M22275 CAS No. 880635-03-0

GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMRT and NCoR.A specific PPARα antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 66 In Stock
10MG 96 In Stock
25MG 204 In Stock
50MG 404 In Stock
100MG 590 In Stock
500MG 1224 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    GW 6471
  • Note
    Research use only, not for human use.
  • Brief Description
    GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMRT and NCoR.A specific PPARα antagonist.
  • Description
    GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMRT and NCoR.A specific PPARα antagonist, GW6471, induced both apoptosis and cell cycle arrest at G0/G1 in VHL(+) and VHL(-) RCC cell lines (786-O and Caki-1) associated with attenuation of the cell cycle regulatory proteins c-Myc, Cyclin D1, and CDK4; this data was confirmed as specific to PPARα antagonism by siRNA methods.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    PPAR
  • Recptor
    PPARα
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    880635-03-0
  • Formula Weight
    619.67
  • Molecular Formula
    C35H36F3N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:120 mg/mL (193.65 mM; Need ultrasonic)
  • SMILES
    CCC(NC[C@@H](N/C(C)=C\C(C1=CC=C(C(F)(F)F)C=C1)=O)CC2=CC=C(OCCC3=C(C)OC(C4=CC=CC=C4)=N3)C=C2)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Abu Aboud O, et al. Inhibition of PPARα induces cell cycle arrest and apoptosis, and synergizes with glycolysisinhibition in kidney cancer cells. PLoS One. 2013 Aug 7;8(8):e71115.
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