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GW 6471
CAS No. 880635-03-0
GW 6471( —— )
Catalog No. M22275 CAS No. 880635-03-0
GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMRT and NCoR.A specific PPARα antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 85 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 46 | In Stock |
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| 10MG | 77 | In Stock |
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| 25MG | 177 | In Stock |
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| 50MG | 305 | In Stock |
|
| 100MG | 523 | In Stock |
|
| 200MG | 786 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGW 6471
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NoteResearch use only, not for human use.
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Brief DescriptionGW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMRT and NCoR.A specific PPARα antagonist.
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DescriptionGW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMRT and NCoR.A specific PPARα antagonist, GW6471, induced both apoptosis and cell cycle arrest at G0/G1 in VHL(+) and VHL(-) RCC cell lines (786-O and Caki-1) associated with attenuation of the cell cycle regulatory proteins c-Myc, Cyclin D1, and CDK4; this data was confirmed as specific to PPARα antagonism by siRNA methods.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetPPAR
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RecptorPPARα
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Research Area——
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Indication——
Chemical Information
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CAS Number880635-03-0
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Formula Weight619.67
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Molecular FormulaC35H36F3N3O4
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Purity>98% (HPLC)
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SolubilityDMSO:120 mg/mL (193.65 mM; Need ultrasonic)
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SMILESCCC(NC[C@@H](N/C(C)=C\C(C1=CC=C(C(F)(F)F)C=C1)=O)CC2=CC=C(OCCC3=C(C)OC(C4=CC=CC=C4)=N3)C=C2)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Abu Aboud O, et al. Inhibition of PPARα induces cell cycle arrest and apoptosis, and synergizes with glycolysisinhibition in kidney cancer cells. PLoS One. 2013 Aug 7;8(8):e71115.
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