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2',5'-Dideoxyadenosine
CAS No. 6698-26-6
2',5'-Dideoxyadenosine( —— )
Catalog No. M22179 CAS No. 6698-26-6
2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 μM).2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 80 | In Stock |
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| 5MG | 72 | In Stock |
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| 10MG | 116 | In Stock |
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| 25MG | 211 | In Stock |
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| 50MG | 346 | In Stock |
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| 100MG | 551 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | 1200 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Name2',5'-Dideoxyadenosine
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NoteResearch use only, not for human use.
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Brief Description2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 μM).2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively.
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Description2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 μM).2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively [2]. 2',5'-Dideoxyadenosine (10 μM, 30 min) reduces cAMP production and blocks the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh). 2',5'-Dideoxyadenosine (10 μM, 30 min) blocks CCh-induced increase of phosphorylation of Akt and attenuates CCh-induced phosphorylation of Ser2448 [3].2',5'-Dideoxyadenosine (0.1 mg/kg; i.p.; 15 min pre-treated) fully inhibits the natriuretic, diuretic and K+ and Cl- sparing effect of FrEtOAc in rats.
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In VitroWestern Blot Analysis Cell Line:Primary hippocampal neurons Concentration:10 μM Incubation Time:30 min Result:Reduced cAMP production and blocked the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh).
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In VivoAnimal Model:Male Wistar rats (3-4 months old)Dosage:0.1 mg/kg Administration:IP; 15 min pre-treated Result:Fully inhibited the diuretic, natriuretic and K+ and Cl- sparing effect of Fr?EtOAc in rats.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorAdenylyl cyclase (AC)
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Research Area——
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Indication——
Chemical Information
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CAS Number6698-26-6
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Formula Weight235.24
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Molecular FormulaC10H13N5O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (531.37 mM)
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SMILESC[C@H]1O[C@H](C[C@@H]1O)n1cnc2c(N)ncnc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bushfield M, et al. Tissue levels, source, and regulation of 3'-AMP: an intracellular inhibitor of adenylyl cyclases. Mol Pharmacol. 1990 Dec;38(6):848-53.
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