Sakuranetin

Research use only, not for human use.

Sakuranetin, a flavanone phytoalexin from ultraviolet-irradiated rice leaves, it has antifungal, antimutagenic, anti-inflammatory and antioxidant effects.

Sakuranetin, a flavanone phytoalexin from ultraviolet-irradiated rice leaves, it has antifungal, antimutagenic, anti-inflammatory and antioxidant effects. Young rice leaves in a resistant line exhibited hypersensitive reaction (HR) within 3 days post inoculation (dpi) of a spore suspension, and an increase in Sakuranetin was detected at 3 dpi, increasing to 4-fold at 4 dpi. In the susceptible line, increased Sakuranetin was detected at 4 dpi, but not at 3 dpi, by which a large fungus mass has accumulated without HR. Induced expression of a PA biosynthesis gene OsNOMT for naringenin 7-O-methyltransferase was found before accumulation of Sakuranetin in both cultivars. The antifungal activity of Sakuranetin was considerably higher than that of the major rice diterpenoid PA momilactone A in vitro and in vivo under similar experimental conditions. The decrease and detoxification of Sakuranetin were detected in both solid and liquid mycelium cultures, and they took place slower than those of momilactone A. Estimated local concentration of Sakuranetin at HR lesions was thought to be effective for fungus restriction, while that at enlarged lesions in susceptible rice was insufficient.

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Animal Model:Acute lung inflammation mice model induced by LPS (5 mg/kg)Dosage:20 mg/kg Administration:intratracheal instillation, 10 μLResult:Reduced respiratory system elastance.Decreased LPS-induced blood and pulmonary leukocytes.Reduced proinflammatory cytokines, markers of M1- and M2-like macrophages, and activation of NF-κB in lung tissue.

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Metabolic Enzyme/Protease

PPAR

PPAR|NF-κB|VEGFR

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2957-21-3

286.29

C16H14O5

>98% (HPLC)

DMSO:125 mg/mL (436.64 mM)

COc1cc(O)c2C(=O)C[C@H](Oc2c1)c1ccc(O)cc1

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(-20℃)

With Ice Pack

≥ 2 years