Cart
sales@molnova.com
Tocilizumab
CAS No. 375823-41-9
Tocilizumab ( —— )
Catalog No. M22142 CAS No. 375823-41-9
Tocilizumab anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 312 | In Stock |
|
| 5MG | 529 | In Stock |
|
| 10MG | 771 | In Stock |
|
| 25MG | 1169 | In Stock |
|
| 50MG | 1553 | In Stock |
|
| 100MG | 2102 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTocilizumab
-
NoteResearch use only, not for human use.
-
Brief DescriptionTocilizumab anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor.
-
DescriptionTocilizumab anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor.
-
In VitroCell Proliferation Assay Cell Line:Human-derived HARA-B cells Concentration:1 ng/mL, 10 ng/mL, and 100 ng/mL Incubation Time:24 hours, 48 hours Result:Inhibited the IL-6R expressed on human-derived HARA-B cells.Cell Cytotoxicity Assay Cell Line:Ba/F3-gp130-IL-6R cells Concentration:0.001–10000 μg/ml Incubation Time:2 days Result:Inhibited Ba/F3-gp130-IL-6R cell proliferation. Western Blot Analysis Cell Line:SAS cells Concentration:1 μM Incubation Time:6 hours Result:Reduced the phosphorylation of STAT3.RT-PCR Cell Line:SAS cells Concentration:1-5 μM Incubation Time:24 hoursResult:Reduced VEGF mRNA expression.
-
In VivoAnimal Model:A brain metastasis model of lung tumor cells by inoculating HARA-B cells in nude mice Dosage:1.0 mg/100 μL Administration:Intravenous injection; 1.0 mg/100 μL; twice a week, three weeks Result:Led the volume of each metastatic focus significantly smaller.Animal Model:SCID mice with SAS cells Dosage:100 μg/mL Administration:Intraperitoneal injection;100 μg/mL; every 48 hours; 20days Result:Suppressed the growth of advanced tumors.
-
Synonyms——
-
PathwayApoptosis
-
TargetIL Receptor
-
RecptorIL Receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number375823-41-9
-
Formula Weight148 kDa
-
Molecular Formula——
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Garbers C, et al. Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor. J Biol Chem. 2011 Dec 16;286(50):42959-70
molnova catalog
related products
-
Umbelliprenin
Umbelliprenin alleviated neuropathic pain, and decreased serum IL-6 levels and oxidative stress.
-
Nothofagin
Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of CAMs, and adhesion and migration of leukocytes, thereby endorsing its usefulness as a therapy for vascular inflammatory diseases.
-
Kaempferol 3-O-β-D-g...
Kaempferol 3-O-β-D-glucuronidee has antioxidant activity. Flavonoid glucuronides can be deconjugated by microsomal α2-glucuronidase from various human cells.
