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Tocilizumab
CAS No. 375823-41-9
Tocilizumab ( —— )
Catalog No. M22142 CAS No. 375823-41-9
Tocilizumab anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 302 | In Stock |
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| 5MG | 501 | In Stock |
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| 10MG | 731 | In Stock |
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| 25MG | 1071 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTocilizumab
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NoteResearch use only, not for human use.
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Brief DescriptionTocilizumab anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor.
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DescriptionTocilizumab anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor.
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In VitroCell Proliferation Assay Cell Line:Human-derived HARA-B cells Concentration:1 ng/mL, 10 ng/mL, and 100 ng/mL Incubation Time:24 hours, 48 hours Result:Inhibited the IL-6R expressed on human-derived HARA-B cells.Cell Cytotoxicity Assay Cell Line:Ba/F3-gp130-IL-6R cells Concentration:0.001–10000 μg/ml Incubation Time:2 days Result:Inhibited Ba/F3-gp130-IL-6R cell proliferation. Western Blot Analysis Cell Line:SAS cells Concentration:1 μM Incubation Time:6 hours Result:Reduced the phosphorylation of STAT3.RT-PCR Cell Line:SAS cells Concentration:1-5 μM Incubation Time:24 hoursResult:Reduced VEGF mRNA expression.
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In VivoAnimal Model:A brain metastasis model of lung tumor cells by inoculating HARA-B cells in nude mice Dosage:1.0 mg/100 μL Administration:Intravenous injection; 1.0 mg/100 μL; twice a week, three weeks Result:Led the volume of each metastatic focus significantly smaller.Animal Model:SCID mice with SAS cells Dosage:100 μg/mL Administration:Intraperitoneal injection;100 μg/mL; every 48 hours; 20days Result:Suppressed the growth of advanced tumors.
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Synonyms——
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PathwayApoptosis
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TargetIL Receptor
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RecptorIL Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number375823-41-9
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Formula Weight148 kDa
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Molecular Formula——
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Garbers C, et al. Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor. J Biol Chem. 2011 Dec 16;286(50):42959-70
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