Cart
sales@molnova.com
LTURM34
CAS No. 1879887-96-3
LTURM34( —— )
Catalog No. M22131 CAS No. 1879887-96-3
LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 58 | In Stock |
|
| 10MG | 102 | In Stock |
|
| 25MG | 222 | In Stock |
|
| 50MG | 385 | In Stock |
|
| 100MG | 575 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameLTURM34
-
NoteResearch use only, not for human use.
-
Brief DescriptionLTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines.
-
DescriptionLTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 170-fold selectivity for DNA-PK over PI3K .LTURM34 is more consistently active against the selected cell lines (11 of 16), but at best shows 54% inhibition against the HOP-92 non-small cell lung cancer line. LTURM34 displays effective inhibition of DNA-PK with excellent selectivity over the Class I PI3K isoforms (IC50s: 5.8 and 8.5 μM for PI3K β and δ, respectively) .
-
In VitroLTURM34 shows potent inhibition of DNA-PK with excellent selectivity over the Class I PI3K isoforms. The IC50s are 5.8 and 8.5 μM for PI3K β and δ, respectively. LTURM34 is more consistently active against the selected cell lines (11 of 16), but at best shows 54% inhibition against the HOP-92 non-small cell lung cancer line.
-
In Vivo——
-
Synonyms——
-
PathwayPI3K/Akt/mTOR signaling
-
TargetPI3K
-
RecptorDNA-PK|PI3Kβ|PI4Kδ
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1879887-96-3
-
Formula Weight414.48
-
Molecular FormulaC24H18N2O3S
-
Purity>98% (HPLC)
-
SolubilityDMSO:60 mg/mL (144.76 mM)
-
SMILESO=c1nc(oc2c(cccc12)-c1cccc2c3ccccc3sc12)N1CCOCC1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Morrison R, et al. Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines. Eur J Med Chem. 2016 Mar 3;110:326-39.
molnova catalog
related products
-
Leniolisib
A novel potent and selective PI3Kδ inhibitor with biochemical IC50 of 11 nM; displays >20-fold, 40-fold, and 200-fold selectivity over PI3Kα, PI3Kβ, and PI3Kγ, respectively.
-
Alkannin
Shikonin is a natural red naphthoquinone pigment has antimicrobial anti-tumor and anti-inflammatory effects; a purified shikonin preparation is widely used for the production of medicinals cosmetics and some food products; shikonin also enters into the antiinflammatory ointment and cream compositions used for the treatment of burns.
-
ZSTK-474
A potent inhibitor of class I PI3K isoforms with IC50 of 17 nM, 53 nM, and 6 nM for p110β, p110γ, and p110δ, respectively.
