Cart
sales@molnova.com
TGX-221
CAS No. 663619-89-4
TGX-221( TGX221 | TGX 221 )
Catalog No. M15529 CAS No. 663619-89-4
A potent, selective PI3K p110β inhibitor with IC50 of 8.5 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 57 | In Stock |
|
| 2MG | 33 | In Stock |
|
| 5MG | 52 | In Stock |
|
| 10MG | 90 | In Stock |
|
| 25MG | 186 | In Stock |
|
| 50MG | 300 | In Stock |
|
| 100MG | 454 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTGX-221
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective PI3K p110β inhibitor with IC50 of 8.5 nM.
-
DescriptionA potent, selective PI3K p110β inhibitor with IC50 of 8.5 nM; weakly inhibits p110δ (IC50=211 nM), and no activity against p110α (IC50>1 uM); inhibits platelet-ECC interaction, platelet aggregation and platelet-granulocyte binding; shows anti-thrombotic effectt devoid of other cardiovascular actions in rats.
-
In Vitro——
-
In Vivo——
-
SynonymsTGX221 | TGX 221
-
PathwayPI3K/Akt/mTOR signaling
-
TargetPI3K
-
Recptorp110α|p110β|p110γ|p110δ
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number663619-89-4
-
Formula Weight364.4409
-
Molecular FormulaC21H24N4O2
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESO=C1C=C(N2CCOCC2)N=C3N1C=C(C)C=C3C(NC4=CC=CC=C4)C
-
Chemical Name4H-Pyrido[1,2-a]pyrimidin-4-one, 7-methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Frazzetto M, et al. Biochem J. 2008 Sep 15;414(3):383-90.
2. Sturgeon SA, et al. Eur J Pharmacol. 2008 Jun 10;587(1-3):209-15.
3. Chaussade C, et al. Biochem J. 2007 Jun 15;404(3):449-58.
4. Straub A, et al. Thromb Haemost. 2008 Mar;99(3):609-15.
molnova catalog
related products
-
AS-252424
AS-252424 is a potent and selective PI3Kγ inhibitor with an IC50 of 30±10 nM.
-
GS-9901
GS-9901 is a selective, orally active and potent PI3Kδ inhibitor (IC50: 1 nM) for the study of non-Hodgkin's lymphoma and chronic lymphocytic leukemia.
-
GDC-0032
GDC-0032 is a potent, next-generation β isoform-sparing PI3K inhibitor targeting PI3Kα/δ/γ with IC50 of 0.29 nM/0.12 nM/0.97nM, >10 fold selective over PI3Kβ.
