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Tripolin A
CAS No. 1148118-92-6
Tripolin A( —— )
Catalog No. M22111 CAS No. 1148118-92-6
Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
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| 10MG | 408 | In Stock |
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| 25MG | 735 | In Stock |
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| 100MG | Get Quote | In Stock |
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Biological Information
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Product NameTripolin A
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NoteResearch use only, not for human use.
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Brief DescriptionTripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively).
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DescriptionTripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively)Tripolin A, a non-ATP competitive inhibitor. Tripolin A reduced the localization of pAurora A on spindle microtubules (MTs), affected centrosome integrity, spindle formation and length, as well as MT dynamics in interphase, consistent with Aurora A inhibition by RNAi or other specific inhibitors, such as MLN8054 or MLN8237. Interestingly, Tripolin A affected the gradient distribution towards the chromosomes, but not the MT binding of HURP (Hepatoma Up-Regulated Protein), a MT-associated protein (MAP) and substrate of the Aurora A kinase. Therefore Tripolin A reveals a new way of regulating mitotic MT stabilizers through Aurora A phosphorylation.
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In VitroTripolin A induces mitotic spindle defects and spindle pole abnormalities.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetAurora Kinase
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RecptorAurora A
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Research Area——
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Indication——
Chemical Information
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CAS Number1148118-92-6
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Formula Weight253.25
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Molecular FormulaC15H11NO3
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Purity>98% (HPLC)
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Solubility——
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SMILESOc3cc(/C=C1\c2ccccc2NC1=O)c(O)cc3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Iliana A Kesisova, et al. Tripolin A, a Novel Small-Molecule Inhibitor of Aurora A Kinase, Reveals New Regulation of HURP's Distribution on Microtubules. PLoS One. 2013;8(3):e58485.
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