Cart
sales@molnova.com
Home -
Products -
Chromatin/Epigenetic -
Epigenetic Reader Domain -
Histone Acetyltransferase Inhibitor II
Histone Acetyltransferase Inhibitor II
CAS No. 932749-62-7
Histone Acetyltransferase Inhibitor II( —— )
Catalog No. M22025 CAS No. 932749-62-7
Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 μM).with anti-acetylase activity in mammalian cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 65 | In Stock |
|
| 10MG | 99 | In Stock |
|
| 25MG | 195 | In Stock |
|
| 50MG | 336 | In Stock |
|
| 100MG | 500 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameHistone Acetyltransferase Inhibitor II
-
NoteResearch use only, not for human use.
-
Brief DescriptionHistone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 μM).with anti-acetylase activity in mammalian cells.
-
DescriptionHistone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 μM).with anti-acetylase activity in mammalian cells. Histone Acetyltransferase Inhibitor II (compound 2c) was the most active inhibitor, also showing high specificity for p300 as compared to other histone acetyltransferases. Most notably, 2c showed anti-acetylase activity in mammalian cells.
-
In VitroHistone Acetyltransferase Inhibitor II (20-40 μM) decreases the levels of H3 acetylation in HeLa-H2B-EYFP cells.
-
In Vivo——
-
Synonyms——
-
PathwayChromatin/Epigenetic
-
TargetEpigenetic Reader Domain
-
Recptorp300
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number932749-62-7
-
Formula Weight464.15
-
Molecular FormulaC20H16Br2O3
-
Purity>98% (HPLC)
-
SolubilityDMSO:30 mg/mL (64.63 mM)
-
SMILESC1CC(=CC2=CC(=C(C=C2)O)Br)C(=O)C(=CC3=CC(=C(C=C3)O)Br)C1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Costi R, et al. Cinnamoyl compounds as simple molecules that inhibit p300 histone acetyltransferase. J Med Chem. 2007 Apr 19;50(8):1973-7. Epub 2007 Mar 10.
molnova catalog
related products
-
C646
C646 is an inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM in a cell-free assay.
-
BY27
BY27, a potent and selective BET BD2 inhibitor (Ki: 3.1 nM) with anticancer activity, inhibits BD1/BD2 of BRD2, BRD3, BRD4, and BRDT, and suppresses tumor growth.
-
dCBP-1
dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 leads to effective multiple myeloma cell killing.
