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MLS000532223
CAS No. 16616-39-0
MLS000532223( —— )
Catalog No. M22012 CAS No. 16616-39-0
MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 318 | In Stock |
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| 5MG | 264 | In Stock |
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| 10MG | 424 | In Stock |
|
| 25MG | 724 | In Stock |
|
| 50MG | 1014 | In Stock |
|
| 100MG | 1386 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMLS000532223
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NoteResearch use only, not for human use.
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Brief DescriptionMLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).
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DescriptionMLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM). MLS000532223, a general inhibitor that prevents GTP binding to several GTPases in a dose-dependent manner and is active in biochemical and cell-based secondary assays. Live-cell imaging and confocal microscopy studies revealed the inhibitor-induced actin reorganization and cell morphology changes, characteristic of Rho GTPases inhibition.
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In VitroMLS000532223 prevents GTP binding to several GTPases in a dose-dependent manner.MLS000532223 modulates Rho-family GTP-binding kinetics.MLS000532223 is active in cell-based assays and inhibits EGF-stimulated Rac 1 activation.MLS000532223 inhibits actin rearrangements and changes in cell morphology that are downstream of Rho family GTPase activation.MLS000532223 (10 μM) modulates actin remodeling in mast cells.MLS000532223 (10 μM) inhibits ligand-stimulated β-hexosaminidase secretion of RBL cells.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorRho family GTPases
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Research Area——
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Indication——
Chemical Information
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CAS Number16616-39-0
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Formula Weight251.24
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Molecular FormulaC15H9NO3
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Purity>98% (HPLC)
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SolubilityDMSO:45mg/ml (179.11 Mm; Need ultrasonic)
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SMILES[O-][N+](=O)C1=CC=CC(=C1)C(=O)C#CC1=CC=CC=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Zurab Surviladze, et al. Identification of a Small GTPase Inhibitor Using a High-Throughput Flow Cytometry Bead-Based Multiplex Assay. J Biomol Screen. 2010 Jan;15(1):10-20.
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