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RET V804M-IN-1

CAS No. 2414909-94-5

RET V804M-IN-1( LUN09945,RETV804M kinase inhibitor )

Catalog No. M22008 CAS No. 2414909-94-5

RET V804M-IN-1 is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 41 Get Quote
5MG 65 Get Quote
10MG 87 Get Quote
25MG 151 Get Quote
50MG 237 Get Quote
100MG 335 Get Quote
200MG 494 Get Quote
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Biological Information

  • Product Name
    RET V804M-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    RET V804M-IN-1 is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).
  • Description
    RET V804M-IN-1 is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).
  • In Vitro
    RET V804M-IN-1 (compound 5) exhibits 3.7 and 110 fold selectivity compared to wt-RET and KDR, respectively.
  • In Vivo
    ——
  • Synonyms
    LUN09945,RETV804M kinase inhibitor
  • Pathway
    Tyrosine Kinase
  • Target
    c-RET
  • Recptor
    RETV804M
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2414909-94-5
  • Formula Weight
    344.37
  • Molecular Formula
    C19H16N6O?
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:120mg/ml (348.46 Mm; Need ultrasonic)
  • SMILES
    NC(=O)C1=CC=C(C=C1)C1=C2N=C(NCC3=CC=CN=C3)C=CN2N=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Rebecca Newton, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET V804M Kinase. ACS Med Chem Lett. 2020 Feb 28;11(4):497-505.
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