RET V804M-IN-1( LUN09945,RETV804M kinase inhibitor )

Catalog No. M22008 CAS No. 2414909-94-5

RET V804M-IN-1 is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	75	In Stock
2MG	43	In Stock
5MG	68	In Stock
10MG	92	In Stock
25MG	160	In Stock
50MG	245	In Stock
100MG	346	In Stock
200MG	511	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

RET V804M-IN-1
Note

Research use only, not for human use.
Brief Description

RET V804M-IN-1 is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).
Description

RET V804M-IN-1 is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).
In Vitro

RET V804M-IN-1 (compound 5) exhibits 3.7 and 110 fold selectivity compared to wt-RET and KDR, respectively.
In Vivo

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Synonyms

LUN09945,RETV804M kinase inhibitor
Pathway

Tyrosine Kinase
Target

c-RET
Recptor

RETV804M
Research Area

——
Indication

——

Chemical Information

CAS Number

2414909-94-5
Formula Weight

344.37
Molecular Formula

C19H16N6O?
Purity

>98% (HPLC)
Solubility

DMSO:120mg/ml (348.46 Mm; Need ultrasonic)
SMILES

NC(=O)C1=CC=C(C=C1)C1=C2N=C(NCC3=CC=CN=C3)C=CN2N=C1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Rebecca Newton, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET V804M Kinase. ACS Med Chem Lett. 2020 Feb 28;11(4):497-505.

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