Cysteine thiol probe

Research use only, not for human use.

Cysteine thiol probe is a chemoselective thiol probe for detection of electrophilic metabolites.

Cysteine thiol probe is a chemoselective thiol probe for detection of electrophilic metabolites.

Cysteine Thiol Probe (Probe 1) reacts much more readily with β-lactam- and β-lactone-based electrophilic natural products, and its reactivity with epoxide-based electrophilic natural products is poor. And probe 2 reacts much faster with epoxide-containing natural products. This orthogonal reactivity allows them to be employed in extracts simultaneously. Since Cysteine Thiol Probe is brominated and probe 2 is chlorinated, the isotopic patterns of labeled natural products point toward their structural origin. Competition experiments using Cysteine Thiol Probe and 2 indicated that brominated Cysteine Thiol Probe reacted exclusively with the β-lactam in penicillin G and the β-lactone in salinosporamide A while chlorinated probe 2 alone reacted with the epoxide in salinamide A.

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Methyl (4-bromobenzoyl)-L-cysteinate

Others

Other Targets

Others

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1947408-74-3

318.19

C11H12BrNO3S

>98% (HPLC)

DMSO:245 mg/ml(769.98 mM; Need ultrasonic)

COC(=O)[C@H](CS)NC(=O)c1ccc(Br)cc1

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(-20℃)

With Ice Pack

≥ 2 years