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BI-409306
CAS No. 1189767-28-9
BI-409306( —— )
Catalog No. M21934 CAS No. 1189767-28-9
BI-409306 is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 41 | In Stock |
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| 5MG | 67 | In Stock |
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| 10MG | 110 | In Stock |
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| 25MG | 178 | In Stock |
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| 50MG | 332 | In Stock |
|
| 100MG | 494 | In Stock |
|
| 200MG | 709 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBI-409306
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NoteResearch use only, not for human use.
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Brief DescriptionBI-409306 is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.
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DescriptionBI-409306 is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.(In Vitro):Osoresnontrine is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 μM), PDE1C (IC50, 1.0 μM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM), and has no obvious effect on 95 non-PDE targets at 10 μM. Osoresnontrine enhances long-term potentiation (LTP) in rat hippocampal slices.
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In VitroOsoresnontrine is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 μM), PDE1C (IC50, 1.0 μM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM), and has no obvious effect on 95 non-PDE targets at 10 μM. Osoresnontrine enhances long-term potentiation (LTP) in rat hippocampal slices.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE9A
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Research AreaNervous system
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IndicationAlzheimer Disease
Chemical Information
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CAS Number1189767-28-9
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Formula Weight311.34
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Molecular FormulaC16H17N5O2
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Purity>98% (HPLC)
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SolubilityDMSO:22 mg/ml(50.06 mM)
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SMILESO=c1[nH]c(Cc2ccccn2)nc2n(ncc12)C1CCOCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cornelia Dorner-Ciossek, R. Giovannini, Holger Rosenbrock. BI 409306, A NOVEL PHOSPHODIESTERASE 9A INHIBITOR, PART I: POTENCY, SELECTIVITY AND IN-VITRO FUNCTIONAL CHARACTERIZATION ON SYNAPTIC PLASTICITY[C]// International Congress on Schizophrenia Research. 2015.
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