ML188

Research use only, not for human use.

ML188 is a selective noncovalent SARS-CoV 3CLpro inhibitor(IC50 : 1.5 μM), with moderate MW and good enzyme and antiviral inhibitory activity.

ML188 is a selective noncovalent SARS-CoV 3CLpro inhibitor(IC50 : 1.5 μM), with moderate MW and good enzyme and antiviral inhibitory activity.Probe 16-(R) (ML188) is a modest molecular weight SARS-CoV 3CLpro inhibitor with demonstrated antiviral activity and a non-covalent mechanism of action.

ML188 (0-30 μM; 48 hours) effectively inhibit SARS-CoV replication in cell culture.Probe ML188 is a modest molecular weight SARS-CoV 3CLpro inhibitor with demonstrated antiviral activity and a non-covalent mechanism of action. ML188 yields an antiviral EC50 value ranging from 12.9 to 13.4 μM in mock-infected and SARS-CoV infected cells. Cell Viability Assay Cell Line:Vero E6 cells (mock-infected or infected with SARS-CoV)Concentration:3, 4, 5, 8,10, 15, 20, 30 μM Incubation Time:48 hour Result:Against mock-infected and SARS-CoV infected cells.

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Others

Other Targets

SARS-CoV

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1417700-13-0

433.54

C26H31N3O3

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (576.65 mM)

CC(C)(C)NC(=O)[C@H](N(C(=O)c1ccco1)c1ccc(cc1)C(C)(C)C)c1cccnc1

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(-20℃)

With Ice Pack

≥ 2 years