E7046( —— )

Catalog No. M21835 CAS No. 1369489-71-3

E7046 is an orally bioavailable and specific EP4 antagonist, with IC50 of 13.5 nM and Ki of 23.14 nM. E7046 exhibits anti-tumor activities.

Purity : >98% (HPLC)

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Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

E7046
Note

Research use only, not for human use.
Brief Description

E7046 is an orally bioavailable and specific EP4 antagonist, with IC50 of 13.5 nM and Ki of 23.14 nM. E7046 exhibits anti-tumor activities.
Description

E7046 is an orally bioavailable and specific EP4 antagonist, with IC50 of 13.5 nM and Ki of 23.14 nM. E7046 exhibits anti-tumor activities.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

GPCR/G Protein
Target

Prostaglandin Receptor
Recptor

——
Research Area

——
Indication

——

Chemical Information

CAS Number

1369489-71-3
Formula Weight

483.39
Molecular Formula

C??H??F?N?O?
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 100 mg/mL (206.87 mM)
SMILES

O=C(O)C1=CC=C([C@@H](NC(C2=C(OC3=CC=CC(C(F)(F)F)=C3)N(C)N=C2C(F)F)=O)C)C=C1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. X. Bao, et al. Combination of a Novel EP4 Antagonist E7046 and Radiation Therapy Promotes Anti-tumor Immune Response and Tumor Rejection in Preclinical Tumor Models. International Journal of Radiation Oncology Biology Physics 2. Diana I. Albu, et al. EP4 Antagonism by E7046 diminishes Myeloid immunosuppression and synergizes with Treg-reducing IL-2-Diphtheria toxin fusion protein in restoring anti-tumor immunity. OncoImmunology.

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