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Travoprost
CAS No. 157283-68-6
Travoprost( Fluprostenol isopropyl ester | AL6221 | Flu-Ipr )
Catalog No. M20546 CAS No. 157283-68-6
Travoprost is used to treat glaucoma and ocular hypertensionis a potent and selective FP prostaglandin receptor agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 88 | In Stock |
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| 5MG | 81 | In Stock |
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| 10MG | 123 | In Stock |
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| 25MG | 185 | In Stock |
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| 50MG | 263 | In Stock |
|
| 100MG | 384 | In Stock |
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| 200MG | 524 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTravoprost
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NoteResearch use only, not for human use.
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Brief DescriptionTravoprost is used to treat glaucoma and ocular hypertensionis a potent and selective FP prostaglandin receptor agonist.
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DescriptionTravoprost is used to treat glaucoma and ocular hypertensionis a potent and selective FP prostaglandin receptor agonist.(In Vitro):Travoprost has sub-micromolar affinity for the DP, EP1, EP3, EP4, IP, and TP receptors.(In Vivo):Travoprost produces a lower incidence of ocular irritation than PGF20 isopropyl ester at a dose of 1 μg in the New Zealand albino (NZA) rabbit. Topical ocular application of Travoprost produces a marked miotic effect in cats following doses of 0.01, 0.03 and 0.1 μg. In the ocular hypertensive monkey, b.i.d. application of 0.1 and 0.3 μg of travoprost afforded peak reduction in intraocular pressure (IOP) of 22.7% and 28.6%, respectively. Topical application of travoprost was well tolerated in rabbits, cats and monkeys, causing no ocular irritation or discomfort at doses up to 1 μg.
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In VitroTravoprost has sub-micromolar affinity for the DP, EP1, EP3, EP4, IP, and TP receptors.
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In VivoTravoprost produces a lower incidence of ocular irritation than PGF20 isopropyl ester at a dose of 1 μg in the New Zealand albino (NZA) rabbit. Topical ocular application of Travoprost produces a marked miotic effect in cats following doses of 0.01, 0.03 and 0.1 μg. In the ocular hypertensive monkey, b.i.d. application of 0.1 and 0.3 μg of travoprost afforded peak reduction in intraocular pressure (IOP) of 22.7% and 28.6%, respectively. Topical application of travoprost was well tolerated in rabbits, cats and monkeys, causing no ocular irritation or discomfort at doses up to 1 μg.
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SynonymsFluprostenol isopropyl ester | AL6221 | Flu-Ipr
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PathwayGPCR/G Protein
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TargetProstaglandin Receptor
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RecptorProstaglandin Receptor
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Research AreaOthers
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Indicationopen-angle glaucoma or ocular hypertension
Chemical Information
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CAS Number157283-68-6
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Formula Weight500.55
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Molecular FormulaC26H35F3O6
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Purity>98% (HPLC)
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SolubilityDMSO:41.67 mg/mL (83.25 mM)
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SMILESCC(C)OC(=O)CCC\C=C/CC1C(O)CC(O)C1\C=C\C(O)COc1cccc(c1)C(F)(F)F
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Chemical Namepropan-2-yl (Z)-7-[(1R2R3R5S)-35-dihydroxy-2-[(E3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Hellberg M R Sallee V L Mclaughlin M A et al. Preclinical Efficacy of Travoprost a Potent and Selective FP Prostaglandin Receptor Agonist[J]. Journal of Ocular Pharmacology and Therapeutics 2001 17(5):421-432.
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