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Home - Products - Metabolic Enzyme/Protease - Other Targets - SI-113

SI-113

CAS No. 1392816-46-4

SI-113 ( —— )

Catalog No. M21730 CAS No. 1392816-46-4

SI-113(SI113;SI 113) is a potent, specific inhibitor of the SGK1 kinase activity, induces autophagy, apoptosis and ER stress in cancer cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SI-113
  • Note
    Research use only, not for human use.
  • Brief Description
    SI-113(SI113;SI 113) is a potent, specific inhibitor of the SGK1 kinase activity, induces autophagy, apoptosis and ER stress in cancer cells.
  • Description
    SI-113(SI113;SI 113) is a potent, specific inhibitor of the SGK1 kinase activity, induces autophagy, apoptosis and ER stress in cancer cells; blocks insulin-dependent phosphorylation of the Sgk1 substrate Mdm2, and induces necrosis and apoptosis in RKO cells; potentiates the effects of paclitaxel on cell viability; active in vivo.
  • In Vitro
    SI-113 exhibits IC50 values of 10.5, 14.4 and 10.7 μM in GIN8, GIN28 and GCE28 GBM cells.SI-113 induces significant increases in caspase-3/7 activation in all GBM cell lines.SI-113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1392816-46-4
  • Formula Weight
    400.486
  • Molecular Formula
    C23H24N6O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (624.25 mM)
  • SMILES
    ——
  • Chemical Name
    2-((4-(phenethylamino)-1-styryl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)ethan-1-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. D'Antona L, et al. Cell Physiol Biochem. 2015;35(5):2006-18. 2. Talarico C, et al. Oncotarget. 2015 Nov 10;6(35):37511-25. 3. Talarico C, et al. Oncotarget. 2016 Mar 29;7(13):15868-84. 4. Radi M, et al. J Med Chem. 2011 Apr 28;54(8):2610-26.
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