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TBK1/IKKε-IN-5
CAS No. 1893397-65-3
TBK1/IKKε-IN-5( —— )
Catalog No. M21640 CAS No. 1893397-65-3
TBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 305 | Get Quote |
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| 10MG | 489 | Get Quote |
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| 25MG | 790 | Get Quote |
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| 50MG | 1071 | Get Quote |
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| 100MG | 1467 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameTBK1/IKKε-IN-5
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NoteResearch use only, not for human use.
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Brief DescriptionTBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM respectively).
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DescriptionTBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM respectively).
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In VitroTBK1/IKKε-IN-5 (0.001-10 μM; 24 or 96 h) promotess secretion of IL-2 and IFN-γ in purified CD4+ and CD8+ T cells and IL-2 in Jurkat human T-cell leukemia cells.TBK1/IKKε-IN-5 effectively blocks immune suppressive cytokine elaboration by CT26 cell line spheroids, without cytotoxic effects. Cell Viability Assay Cell Line:CD4+ and CD8+ T cells, Jurkat T cell leukemia cells Concentration:0.001-10 μM Incubation Time:24 h (for IL-2); 96 h(for IFN-γ)Result:Enhanced secretion of IL-2 and IFN-γ.
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In VivoTBK1/IKKε-IN-5 (40 mg/kg; p.o.; single daily for 26 days) shows good antitumor activity and prolongs survival, as well as induces immunologic memory of CT26 cells in mice when combines with anti-PD-L1. Animal Model:Female Balb/c mice (11 to 12-week-old; bearing CT26 tumors).Dosage:40 mg/kg Administration:Oral gavage; single daily for 26 days (combine with anti-PD-L1).Result:Exhibited greater tumor control and longer survival when combined with anti-PD-L1 than used alone of both agents.Induced immunologic memory of CT26 cells in mice when combined with anti-PD-L1.
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Synonyms——
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PathwayImmunology/Inflammation
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TargetIκB kinase (IKK)
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RecptorTBK1| IKK?
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Research Area——
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Indication——
Chemical Information
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CAS Number1893397-65-3
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Formula Weight513.59
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Molecular FormulaC28H31N7O3
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Purity>98% (HPLC)
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SolubilityDMSO:7.81 mg/mL (15.21 mM; Need ultrasonic)
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SMILESN#Cc1cc(ccc1OC1CCOCC1)-c1ncnc(Nc2ccc(cc2)N2CCN(CC2)C2COC2)n1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Jenkins RW et al. Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids. Cancer Discov. 2018 Feb;8(2):196-215.
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