IKK2-IN-9( —— )

Catalog No. M11120 CAS No. 1266240-89-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

IKK2-IN-9
Note

Research use only, not for human use.
Brief Description

IKK2-IN-9 is a potent, selective and orally active IKK2 inhibitor with IC50 of 19 nM.
Description

IKK2-IN-9 is a potent, selective and orally active IKK2 inhibitor with IC50 of 19 nM, displays 20-fold selectivity over IKK1 (IC50=420 nM); inhibits lipopolysaccharide (LPS) induced TNFα production in human PBMCs with IC50 of 0.22 uM; dose-dependently inhibist the TNF-α response in murine model of acute inflammation.
In Vitro

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In Vivo

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Synonyms

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Pathway

Immunology/Inflammation
Target

IκB kinase (IKK)
Recptor

IκB kinase (IKK)
Research Area

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Indication

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CAS Number

1266240-89-4
Formula Weight

394.497
Molecular Formula

C20H22N6OS
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

(S)-N-(1-(3-(5-(ethylamino)-8-methyl-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl)phenyl)ethyl)acetamide

1. Dyckman AJ, et al. Bioorg Med Chem Lett. 2011 Jan 1;21(1):383-6.

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