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Bardoxolone Methyl
CAS No. 218600-53-4
Bardoxolone Methyl( Bardoxolone methyl | NSC 713200 | RTA 402 | TP-155 )
Catalog No. M13487 CAS No. 218600-53-4
Bardoxolone Methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities. Phase 3.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 41 | In Stock |
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| 10MG | 37 | In Stock |
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| 25MG | 56 | In Stock |
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| 50MG | 74 | In Stock |
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| 100MG | 113 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | 310 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBardoxolone Methyl
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NoteResearch use only, not for human use.
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Brief DescriptionBardoxolone Methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities. Phase 3.
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DescriptionBardoxolone Methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities. Phase 3.(In Vivo):Bardoxolone methyl (30 mg/kg, p.o.) decreases renal expression of megalin but not cubilin, increases creatinine clearance and urinary albumin-to-creatinine ratios, and induces Nrf2 cytoprotective targets in cynomolgus monkeys. Bardoxolone methyl induces overall favorable effects on the heart via its improvement in eGFR in both animal models and clinical trials.
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In Vitro——
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In VivoBardoxolone methyl (30 mg/kg, p.o.) decreases renal expression of megalin but not cubilin, increases creatinine clearance and urinary albumin-to-creatinine ratios, and induces Nrf2 cytoprotective targets in cynomolgus monkeys. Bardoxolone methyl induces overall favorable effects on the heart via its improvement in eGFR in both animal models and clinical trials.
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SynonymsBardoxolone methyl | NSC 713200 | RTA 402 | TP-155
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PathwayImmunology/Inflammation
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TargetIκB kinase (IKK)
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RecptorIKK
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number218600-53-4
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Formula Weight505.69
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Molecular FormulaC32H43NO4
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Purity>98% (HPLC)
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SolubilityDMSO:21 mg/mL (41.52 mM); Ethanol:<1 mg/mL (<1 mM); Water:<1 mg/mL (<1 mM)
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SMILESO=C([C@]1(CC[C@@]2(C)[C@]3(C)CCC4C(C)(C)C(C(C#N)=C[C@]4(C)C3=C5)=O)CCC(C)(C)C[C@]1([H])[C@@]2([H])C5=O)OC
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Chemical Name(4aS,6aR,6bS,12aS,14aR,14bR)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Honda T, et al. J Med Chem. 2000, 43(22), 4233-4246.
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