BIO-013077-01

Research use only, not for human use.

BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.

BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.

A wide range of cellular functions such as cell proliferation, differentiation, adhesion, migration, and apoptosis are regulated by TGF-β superfamily members. The TGF-βs include the three major TGF-β isoforms, TGF-β1, TGF-β2, and TGF-β3 which are expressed in mammals. TGF-β transduces signals through a complex of two related but structurally and functionally distinct serine/threonine kinase receptors, termed type 1 and type II. Deregulation of TGF-β signaling has been also implicated in various human diseases including cancer, pancreatic diseases, and hematological malignancies.

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Others

Other Targets

TGFβ

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746667-48-1

287.32

C17H13N5

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (348.04 mM)

Cc1cccc(n1)-c1n[nH]cc1-c1ccc2nccnc2c1

6-[3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoxaline

(-20℃)

With Ice Pack

≥ 2 years